PMID- 12885583
OWN - NLM
STAT- MEDLINE
DCOM- 20030912
LR  - 20190910
IS  - 0197-4580 (Print)
IS  - 0197-4580 (Linking)
VI  - 24
IP  - 5
DP  - 2003 Sep
TI  - Age-related changes in cerebral lactate metabolism in sleep-disordered breathing.
PG  - 753-60
AB  - Thirty-one patients, aged 22-71 years, with nocturnal apneic episodes and/or 
      habitual snoring were studied with magnetic resonance spectroscopy (MRS) and 
      diagnostic polysomnography separately to determine whether accumulation of 
      lactate caused by cerebral hypoxia during sleep is associated with 
      sleep-disordered breathing (SDB), aging and co-morbidities related to SDB. Eight 
      proton magnetic resonance spectra for sleep and two for periods of arousal were 
      obtained from the right centrum semiovale. All patients were evaluated for the 
      presence or absence of co-morbidities including hypertension, cardiac disease, 
      diabetes mellitus, and hyperlipidemia. Significant lactate signals were found in 
      seven patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) during 
      sleep periods, and none during periods of arousal. Aging was significantly 
      related to the presence or absence of significant lactate signals during sleep 
      periods as determined by logistic regression analysis (beta=0.2480; 95% 
      confidence interval, 0.0905-0.5094; P=0.0001). Apnea index (AI), apnea-hypopnea 
      index (AHI), and minimum value of peripheral oxyhemoglobin saturation each 
      significantly interacted with age (P=0.0081, 0.0284, and 0.0302, respectively). 
      Our findings suggest that SDB combined with aging is related to accumulation of 
      lactate during sleep.
FAU - Kamba, Masayuki
AU  - Kamba M
AD  - Ogawa Laboratories for Brain Function Research, Hamano Life Science Research 
      Foundation, 12 Daikyo-cho, Shinjuku-ku, 160-0015, Tokyo, Japan. kamba@hlsrf.or.jp
FAU - Inoue, Yuichi
AU  - Inoue Y
FAU - Higami, Shigeru
AU  - Higami S
FAU - Suto, Yuji
AU  - Suto Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging/*physiology
MH  - Apnea/metabolism
MH  - Body Mass Index
MH  - Cerebral Cortex/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Lactic Acid/*metabolism
MH  - Magnetic Resonance Spectroscopy/instrumentation/methods
MH  - Male
MH  - Middle Aged
MH  - Polysomnography/instrumentation/methods
MH  - Regression Analysis
MH  - Sleep Apnea Syndromes/*metabolism/pathology
MH  - Sleep Stages/physiology
EDAT- 2003/07/30 05:00
MHDA- 2003/09/13 05:00
CRDT- 2003/07/30 05:00
PHST- 2003/07/30 05:00 [pubmed]
PHST- 2003/09/13 05:00 [medline]
PHST- 2003/07/30 05:00 [entrez]
AID - S0197458002001914 [pii]
AID - 10.1016/s0197-4580(02)00191-4 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2003 Sep;24(5):753-60. doi: 10.1016/s0197-4580(02)00191-4.