PMID- 12887016
OWN - NLM
STAT- MEDLINE
DCOM- 20040406
LR  - 20190922
IS  - 0145-479X (Print)
IS  - 0145-479X (Linking)
VI  - 35
IP  - 2
DP  - 2003 Apr
TI  - Mitochondrial dysfunctions during aging: vitamin E deficiency or caloric 
      restriction--two different ways of modulating stress.
PG  - 181-91
AB  - Caloric restriction (CR), which has been demonstrated to offset the 
      age-associated accrual of oxidative injury, involves a reduction in calory intake 
      while maintaining adequate nutrition, preserves the activities of antioxidant 
      enzymes in postmitotic tissues, maintains organ function, opposes the development 
      of spontaneous diseases, and prolongs maximum life span in laboratory rodents. It 
      has been proposed that reductions in Reactive Oxygen Species (ROS) production and 
      cellular oxidative injury are central to the positive effects of CR. In the 
      present investigation we studied the effect of CR and of a vitamin E deprived 
      diet on mitochondrial structure and features in the liver of rats during aging, 
      in order to ascertain the extent of modifications induced by these experimental 
      conditions. CR rats displayed structural and functional mitochondrial properties 
      (fatty acid pattern, respiratory chain activities, antioxidant levels, and 
      hydroperoxide contents) similar to those of younger rats whilst vitamin E 
      deficient rats appeared older than their own age. The mitochondria of the former, 
      together with those of young rats, possessed the lowest Coenzyme Q9, 
      hydroperoxide, and cytochrome contents as well as a suitable fatty acid membrane 
      composition. Our study confirms that CR is a valuable tool in limiting 
      aging-related free-radical damage also at mitochondrial liver level.
FAU - Armeni, Tatiana
AU  - Armeni T
AD  - Institute of Biology and Genetics, University of Ancona, Ancona, Italy.
FAU - Principato, Giovanni
AU  - Principato G
FAU - Quiles, Jose L
AU  - Quiles JL
FAU - Pieri, Carlo
AU  - Pieri C
FAU - Bompadre, Stefano
AU  - Bompadre S
FAU - Battino, Maurizio
AU  - Battino M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Bioenerg Biomembr
JT  - Journal of bioenergetics and biomembranes
JID - 7701859
RN  - 0 (Cytochromes)
RN  - 0 (Fatty Acids)
RN  - 0 (Reactive Oxygen Species)
RN  - 1339-63-5 (Ubiquinone)
RN  - BBX060AN9V (Hydrogen Peroxide)
SB  - IM
MH  - Adaptation, Physiological
MH  - *Aging
MH  - Animals
MH  - *Caloric Restriction
MH  - Cell Respiration
MH  - Cells, Cultured
MH  - Cytochromes/metabolism
MH  - Fatty Acids/metabolism
MH  - Female
MH  - Hydrogen Peroxide/metabolism
MH  - Mitochondria, Liver/*metabolism
MH  - *Oxidative Stress
MH  - Rats
MH  - Rats, Wistar
MH  - Reactive Oxygen Species/*metabolism
MH  - Stress, Physiological/etiology/*metabolism
MH  - Survival Analysis
MH  - Ubiquinone/metabolism
MH  - Vitamin E Deficiency/complications/*metabolism
EDAT- 2003/07/31 05:00
MHDA- 2004/04/07 05:00
CRDT- 2003/07/31 05:00
PHST- 2003/07/31 05:00 [pubmed]
PHST- 2004/04/07 05:00 [medline]
PHST- 2003/07/31 05:00 [entrez]
AID - 10.1023/a:1023754305218 [doi]
PST - ppublish
SO  - J Bioenerg Biomembr. 2003 Apr;35(2):181-91. doi: 10.1023/a:1023754305218.