PMID- 12887239
OWN - NLM
STAT- MEDLINE
DCOM- 20031112
LR  - 20191210
IS  - 0899-823X (Print)
IS  - 0899-823X (Linking)
VI  - 24
IP  - 7
DP  - 2003 Jul
TI  - Evaluation of the antimicrobial efficacy of urinary catheters impregnated with 
      antiseptics in an in vitro urinary tract model.
PG  - 506-13
AB  - OBJECTIVES: To evaluate the long-term efficacy of urinary Foley catheters (latex 
      and silicone) impregnated with (1) chlorhexidine and silver sulfadiazine (CXS) 
      and (2) chlorhexidine, silver sulfadiazine, and triclosan (CXST) in inhibiting 
      extra-luminal bacterial adherence and to compare their efficacy with that of 
      silver hydrogel latex (SH) and nitrofurazone-treated silicone (NF) catheters. 
      DESIGN: The antimicrobial spectrum of these catheters was evaluated using a zone 
      of inhibition assay. A novel in vitro urinary tract model was developed to study 
      the potential in vivo efficacy of antimicrobial catheters in preventing 
      extraluminal bacterial colonization. The "meatus" was inoculated daily with 
      Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Enterococcus 
      faecalis, Pseudomonas aerginosa, and Candida albicans. The "bladder" portion of 
      the model was cultured daily to determine bacterial growth. RESULTS: Both CXS and 
      CXST catheters had a broader antimicrobial spectrum than SH and NF catheters. In 
      the in vitro model, CXST latex and silicone catheters exhibited significantly 
      better efficacy (3 to 25days) against uropathogens, compared with CXS (1 to 14 
      days) and control (0 to 5 days) catheters (P = .01). CXST latex catheters 
      exhibited significantly longer protection against Staphylococcus aureus, 
      Staphylococcus epidermidis, Escherichia coli, and Pseudomonas aeruginosa, 
      compared with SH catheters (P = .01). CXST silicone catheters resisted 
      colonization with Staphylococcus aureus and Staphylococcus epidermidis for a 
      significantly longer period (23 to 24 days) than did NF catheters (9 to 11 days) 
      (P = .01). CONCLUSION: Catheters impregnated with synergistic combinations of 
      chlorhexidine, silver sulfadiazine, and triclosan exhibited broad-spectrum, 
      long-term resistance against microbial colonization on their outer surfaces.
FAU - Gaonkar, Trupti A
AU  - Gaonkar TA
AD  - Department of Surgery, College of Physicians and Surgeons, Columbia University, 
      New York, New York 10032, USA.
FAU - Sampath, Lester A
AU  - Sampath LA
FAU - Modak, Shanta M
AU  - Modak SM
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - Infect Control Hosp Epidemiol
JT  - Infection control and hospital epidemiology
JID - 8804099
RN  - 0 (Anti-Infective Agents, Urinary)
RN  - 4NM5039Y5X (Triclosan)
RN  - R4KO0DY52L (Chlorhexidine)
RN  - W46JY43EJR (Silver Sulfadiazine)
SB  - IM
MH  - Anti-Infective Agents, Urinary/*administration & dosage/classification
MH  - Bacteria/drug effects
MH  - Catheters, Indwelling
MH  - Chlorhexidine/administration & dosage/pharmacology
MH  - Colony Count, Microbial
MH  - *Drug Delivery Systems
MH  - Humans
MH  - In Vitro Techniques
MH  - Models, Biological
MH  - Silver Sulfadiazine/administration & dosage/pharmacology
MH  - Treatment Outcome
MH  - Triclosan/administration & dosage/pharmacology
MH  - United States
MH  - Urinary Catheterization/*instrumentation
EDAT- 2003/07/31 05:00
MHDA- 2003/11/13 05:00
CRDT- 2003/07/31 05:00
PHST- 2003/07/31 05:00 [pubmed]
PHST- 2003/11/13 05:00 [medline]
PHST- 2003/07/31 05:00 [entrez]
AID - ICHE5720 [pii]
AID - 10.1086/502241 [doi]
PST - ppublish
SO  - Infect Control Hosp Epidemiol. 2003 Jul;24(7):506-13. doi: 10.1086/502241.