PMID- 12888255
OWN - NLM
STAT- MEDLINE
DCOM- 20040329
LR  - 20191026
IS  - 0753-3322 (Print)
IS  - 0753-3322 (Linking)
VI  - 57
IP  - 5-6
DP  - 2003 Jul-Aug
TI  - The anti-ageing effects of caloric restriction may involve stimulation of 
      macroautophagy and lysosomal degradation, and can be intensified 
      pharmacologically.
PG  - 203-8
AB  - Caloric restriction (CR) and a reduced growth hormone (GH)-insulin-like growth 
      factor (IGF-1) axis are associated with an extension of lifespan across taxa. 
      Evidence is reviewed showing that CR and reduced insulin of GH-IGF-1 axis may 
      exhibit their effects at least partly by their common stimulatory action on 
      autophagy, the cell repair mechanism responsible for the housekeeping of cell 
      membranes and organelles including the free radical generators peroxisomes and 
      mitochondria. It is shown that the life-long weekly administration of an 
      anti-lipolytic drug may decrease glucose and insulin levels and stimulate 
      autophagy and intensify anti-ageing effects of submaximal CR.
FAU - Bergamini, E
AU  - Bergamini E
AD  - Centro di Ricerca di Biologia e Patologia dell'Invecchiamento, University of 
      Pisa, Scuola Medica, Via Roma 55, 56126 Pisa, Italy. ebergami@ipg.med.unipi.it
FAU - Cavallini, G
AU  - Cavallini G
FAU - Donati, A
AU  - Donati A
FAU - Gori, Z
AU  - Gori Z
LA  - eng
PT  - Journal Article
PT  - Review
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Hypolipidemic Agents)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Aging/drug effects/*metabolism
MH  - Animals
MH  - Autophagy/*drug effects/genetics
MH  - *Caloric Restriction
MH  - Gene Expression/drug effects
MH  - Humans
MH  - Hypolipidemic Agents/*pharmacology
MH  - Insulin-Like Growth Factor I/genetics/metabolism
MH  - Lysosomes/*drug effects/metabolism
RF  - 57
EDAT- 2003/07/31 05:00
MHDA- 2004/03/30 05:00
CRDT- 2003/07/31 05:00
PHST- 2003/07/31 05:00 [pubmed]
PHST- 2004/03/30 05:00 [medline]
PHST- 2003/07/31 05:00 [entrez]
AID - S0753332203000489 [pii]
AID - 10.1016/s0753-3322(03)00048-9 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2003 Jul-Aug;57(5-6):203-8. doi: 
      10.1016/s0753-3322(03)00048-9.