PMID- 12888635
OWN - NLM
STAT- MEDLINE
DCOM- 20031106
LR  - 20180330
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 133
IP  - 8
DP  - 2003 Aug
TI  - Obesity risk is associated with carbohydrate intake in women carrying the 
      Gln27Glu beta2-adrenoceptor polymorphism.
PG  - 2549-54
AB  - Interindividual differences in the response to dietary intake are, in some cases, 
      genotype dependent. Moreover, genotype-environment interactions may appear when 
      the impact of lifestyle factors (e.g., diet) on a phenotype (e.g., BMI > 30 
      kg/m(2)) differs by genotype. A case-control study (obese subjects vs. normal 
      weight controls) was conducted to assess a possible effect modification on 
      obesity risk of the Gln27Glu polymorphism for the beta(2)-adrenoceptor gene 
      depending on dietary intake. The sample included 159 subjects with BMI > 30 
      kg/m(2) and 154 controls with BMI < 25 kg/m(2). The allele frequency for the 
      Glu27 polymorphism, as assessed by the polymerase chain reaction-restriction 
      fragment length polymorphism methodology, was 0.40 in cases (obese) and 0.37 in 
      controls (lean), which was similar to that of other Caucasian populations. The 
      dietary intake was estimated by using a previously validated food frequency 
      questionnaire. Obesity incidence was not directly affected by the polymorphism 
      [odds ratio (OR) = 1.40; P = 0.246]. However, a significant interaction (effect 
      modification) between carbohydrate (CHO) intake and the presence of the Glu27 
      variant in the probability of obesity was apparent. Thus, females with the 
      polymorphism and a higher CHO intake [>49% energy (E)] had a higher obesity risk 
      (OR = 2.56, P = 0.051). The product-term introduced in the logistic model to 
      assess effect modification revealed a marginally significant interaction (P = 
      0.058) between both factors. Furthermore, a high intake of CHO (E > 49%) was 
      associated with higher insulin levels among women carrying the Gln27Glu 
      polymorphism (P < 0.01). This gene-nutrient interaction emphasizes the importance 
      of examining the outcome of some obesity-related mutations depending on lifestyle 
      (including diet) and may explain the heterogeneity of findings from previous 
      studies.
FAU - Martinez, J Alfredo
AU  - Martinez JA
AD  - Department of Physiology and Nutrition, University of Navarra, 31008 Pamplona, 
      Spain. jalfmtz@unav.es
FAU - Corbalan, Maria S
AU  - Corbalan MS
FAU - Sanchez-Villegas, Almudena
AU  - Sanchez-Villegas A
FAU - Forga, Luis
AU  - Forga L
FAU - Marti, Amelia
AU  - Marti A
FAU - Martinez-Gonzalez, Miguel A
AU  - Martinez-Gonzalez MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Insulin)
RN  - 0 (Receptors, Adrenergic, beta-2)
RN  - 0RH81L854J (Glutamine)
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Glutamic Acid
MH  - Glutamine
MH  - Humans
MH  - Insulin/blood
MH  - Male
MH  - Middle Aged
MH  - Obesity/*genetics
MH  - *Polymorphism, Genetic
MH  - Receptors, Adrenergic, beta-2/*genetics
MH  - *Sex Characteristics
EDAT- 2003/07/31 05:00
MHDA- 2003/11/07 05:00
CRDT- 2003/07/31 05:00
PHST- 2003/07/31 05:00 [pubmed]
PHST- 2003/11/07 05:00 [medline]
PHST- 2003/07/31 05:00 [entrez]
AID - 10.1093/jn/133.8.2549 [doi]
PST - ppublish
SO  - J Nutr. 2003 Aug;133(8):2549-54. doi: 10.1093/jn/133.8.2549.