PMID- 12889104
OWN - NLM
STAT- MEDLINE
DCOM- 20040907
LR  - 20131121
IS  - 0412-3948 (Print)
IS  - 0412-3948 (Linking)
VI  - 38
IP  - 2
DP  - 2003 Apr
TI  - [Cisplatin-induced apoptotic cell death in spiral ganglion and organ of Corti of 
      mongolian gerbil cochlear].
PG  - 98-100
AB  - OBJECTIVE: To investigate whether apoptosis is one of the mechanism for cell 
      death in spiral ganglion(SG) and organ of Corti of Mongolian gerbils cochlea 
      induced by cisplatin. METHODS: Mongolian gerbils were administered 4 mg.kg-1.d-1 
      cisplatin consecutively for 4 to 7 days. The apoptotic cell death in spiral 
      ganglion and organ of Corti of cochlea basal turn was detected via transmission 
      electron microscopy and terminal deoxynucleotidyl transferase-mediated dUTP nick 
      end labeling (TUNEL) method. RESULTS: The observation of electron microscopy 
      shown special morphological change consistent with the feature of cell apoptosis 
      in some spiral ganglion cells and outer hair cells after 5-7 days' cisplatin 
      treatment. The apoptotic labeling by TUNEL in spiral ganglion and organ of Corti 
      was detected after 5 days' treatment and increased after 6 and 7 days' treatment 
      whereas almost negative result were obtained in the normal control animals. 
      CONCLUSION: Apoptosis is one of the important mechanisms for cell injury of 
      spiral ganglion and organ of Corti induced by cisplatin.
FAU - Xu, Hui-jie
AU  - Xu HJ
AD  - Department of Otorhinolaryngology, Beijing Hospital, Beijing 100730, China. 
      xuhuijie@yahoo.com
FAU - Huang, Wei-ning
AU  - Huang WN
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Bi Yan Hou Ke Za Zhi
JT  - Zhonghua er bi yan hou ke za zhi
JID - 16210350R
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - Cisplatin/*toxicity
MH  - Cochlea/cytology/*drug effects
MH  - Female
MH  - Gerbillinae
MH  - In Situ Nick-End Labeling
MH  - Neurons/drug effects
MH  - Organ of Corti/*cytology/drug effects
MH  - Spiral Ganglion/*cytology/drug effects
EDAT- 2003/08/02 05:00
MHDA- 2004/09/08 05:00
CRDT- 2003/08/02 05:00
PHST- 2003/08/02 05:00 [pubmed]
PHST- 2004/09/08 05:00 [medline]
PHST- 2003/08/02 05:00 [entrez]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Ke Za Zhi. 2003 Apr;38(2):98-100.