PMID- 12889122
OWN - NLM
STAT- MEDLINE
DCOM- 20040419
LR  - 20111117
IS  - 0513-4870 (Print)
IS  - 0513-4870 (Linking)
VI  - 38
IP  - 4
DP  - 2003 Apr
TI  - Studies on antidiabetic effects of cortex Moutan polysaccharide-2b in type 2 
      diabetes mellitus rats.
PG  - 255-9
AB  - AIM: To study the antidiabetic effects of cortex Moutan polysaccharide-2b 
      (CMP-2b) in type 2 diabetes mellitus (T2DM) rats. METHODS: The T2DM model rats 
      were induced by a single intravenous injection of low dose streptozotocin (STZ) 
      and intake of high sucrose-fat diet. CMP-2b was given to T2DM rats daily through 
      gavage for 4-5 weeks. The body weight, water and food intake, fasting blood 
      glucose (FBG), glucose tolerance, plasma lipids, serum insulin, and insulin 
      receptor (Ins R) were determined. RESULTS: Oral administration of CMP-2b 
      significantly decreased water and food intake, FBG, total cholesterol (Tch), and 
      triglyceride (TG), improved the impaired glucose tolerance (IGT), and remarkably 
      raised the number of low affinity InsR and insulin sensitivity index (ISI) in 
      T2DM rats. CONCLUSION: CMP-2b may be useful for treating T2DM and its 
      complications.
FAU - Hong, Hao
AU  - Hong H
AD  - Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, 
      China.
FAU - Wang, Qin-mao
AU  - Wang QM
FAU - Zhao, Zhi-ping
AU  - Zhao ZP
FAU - Liu, Guo-qing
AU  - Liu GQ
FAU - Shen, Ye-shou
AU  - Shen YS
FAU - Chen, Guang-liang
AU  - Chen GL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Yao Xue Xue Bao
JT  - Yao xue xue bao = Acta pharmaceutica Sinica
JID - 21710340R
RN  - 0 (Blood Glucose)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Polysaccharides)
RN  - 0 (moutan cortex)
RN  - EC 2.7.10.1 (Receptor, Insulin)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Body Weight/drug effects
MH  - Diabetes Mellitus, Experimental/*drug therapy
MH  - Drugs, Chinese Herbal/*chemistry
MH  - Glucose Intolerance
MH  - Hypoglycemic Agents/isolation & purification/*therapeutic use
MH  - Insulin/blood
MH  - Liver/metabolism
MH  - Male
MH  - Paeonia/chemistry
MH  - Plant Roots/chemistry
MH  - Plants, Medicinal/chemistry
MH  - Polysaccharides/isolation & purification/*therapeutic use
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, Insulin/*metabolism
EDAT- 2003/08/02 05:00
MHDA- 2004/04/20 05:00
CRDT- 2003/08/02 05:00
PHST- 2003/08/02 05:00 [pubmed]
PHST- 2004/04/20 05:00 [medline]
PHST- 2003/08/02 05:00 [entrez]
PST - ppublish
SO  - Yao Xue Xue Bao. 2003 Apr;38(4):255-9.