PMID- 12889601
OWN - NLM
STAT- MEDLINE
DCOM- 20031110
LR  - 20151119
IS  - 0167-6806 (Print)
IS  - 0167-6806 (Linking)
VI  - 80
IP  - 1
DP  - 2003 Jul
TI  - Expression of estrogen receptor-beta in normal mammary and tumor tissues: is it 
      protective in breast carcinogenesis?
PG  - 79-85
AB  - Using messenger RNA (mRNA) in situ hybridization, we investigated estrogen 
      receptor-beta (ERbeta) mRNA levels in normal mammary, benign breast tumor (BBT), 
      breast cancer (BC), and metastatic lymph node tissues to verify the role of 
      ERbeta in BC development and progression. ERbeta expression was significantly 
      decreased in BC and metastatic lymph node tissues compared with normal mammary 
      and BBT tissues (p < 0.01). The intensity and extent of ERbeta mRNA signals were 
      also significantly lower in BC and metastatic lymph node tissues than in the 
      normal mammary and BBT tissues (p < 0.01). An inverse relationship was found 
      between ERbeta mRNA level and both histologic grade (p = 0.091) and progesterone 
      receptor expression (p = 0.052) with marginal significance, but no significant 
      association was noted between ERbeta expression in cancer tissues and the other 
      clinico-pathologic data. The 3-year distant relapse-free survival probability was 
      found to be independent of ERbeta expression. Collectively, ERbeta mRNA decreases 
      in the process of BC development, but seems to be associated with poor 
      differentiation.
FAU - Park, Byeong-Woo
AU  - Park BW
AD  - Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea. 
      bwpark@yumc.yonsei.ac.kr
FAU - Kim, Ki-Suk
AU  - Kim KS
FAU - Heo, Min-Kyu
AU  - Heo MK
FAU - Ko, Seung-Sang
AU  - Ko SS
FAU - Hong, Soon Won
AU  - Hong SW
FAU - Yang, Woo-Ick
AU  - Yang WI
FAU - Kim, Joo-Hang
AU  - Kim JH
FAU - Kim, Gwi Eon
AU  - Kim GE
FAU - Lee, Kyong Sik
AU  - Lee KS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Breast Cancer Res Treat
JT  - Breast cancer research and treatment
JID - 8111104
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA, Neoplasm)
RN  - 0 (Receptors, Estrogen)
SB  - IM
MH  - Biomarkers, Tumor/*metabolism
MH  - Breast Neoplasms/genetics/*metabolism/*pathology
MH  - Disease-Free Survival
MH  - Estrogen Receptor beta
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - In Situ Hybridization
MH  - Lymphatic Metastasis
MH  - Prognosis
MH  - RNA, Messenger/metabolism
MH  - RNA, Neoplasm/metabolism
MH  - Receptors, Estrogen/genetics/*metabolism
EDAT- 2003/08/02 05:00
MHDA- 2003/11/11 05:00
CRDT- 2003/08/02 05:00
PHST- 2003/08/02 05:00 [pubmed]
PHST- 2003/11/11 05:00 [medline]
PHST- 2003/08/02 05:00 [entrez]
AID - 10.1023/A:1024406223619 [doi]
PST - ppublish
SO  - Breast Cancer Res Treat. 2003 Jul;80(1):79-85. doi: 10.1023/A:1024406223619.