PMID- 12890042
OWN - NLM
STAT- MEDLINE
DCOM- 20040130
LR  - 20190910
IS  - 1045-3873 (Print)
IS  - 1045-3873 (Linking)
VI  - 14
IP  - 8
DP  - 2003 Aug
TI  - Prognostic significance of heart rate turbulence following ventricular premature 
      beats in patients with idiopathic dilated cardiomyopathy.
PG  - 819-24
AB  - Heart Rate Turbulence in Dilated Cardiomyopathy. INTRODUCTION: The aim of this 
      study was to investigate the prognostic significance of heart rate turbulence 
      (HRT) characterized by HRT onset and slope after ventricular premature beats in 
      patients with idiopathic dilated cardiomyopathy (IDC). METHODS AND RESULTS: 
      Blinded HRT analysis was performed in 242 patients with IDC who were enrolled in 
      the Marburg Cardiomyopathy database between 1992 and 2000. During 41 +/- 23 
      months of follow-up, 54 patients (22%) died or underwent heart transplant. On Cox 
      univariate regression analysis, abnormal HRT onset, HRT slope, HRT onset combined 
      with HRT slope, left ventricular (LV) ejection fraction, LV size, and New York 
      Heart Association (NYHA) functional class III showed a significant association 
      with total mortality or the need for heart transplant. On multivariate analysis, 
      abnormal HRT onset identified patients without transplant-free survival, as did 
      LV size and NYHA class III heart failure. Major arrhythmic events were observed 
      in 42 patients (17%) during follow-up. On univariate analysis, abnormal HRT 
      onset, HRT onset combined with HRT slope, male sex, NYHA class III, LV ejection 
      fraction, and LV size were associated with a higher incidence of major arrhythmic 
      events. On multivariate analysis, only LV ejection fraction remained as a 
      significant arrhythmia risk predictor, with a relative risk of 2.2 per 10% 
      decrease in ejection fraction (95% confidence interval 1.5-3.2). CONCLUSION: In 
      this selected patient population with IDC, HRT onset is a significant predictor 
      of transplant-free survival, as are LV size and NYHA class. For arrhythmia risk 
      stratification, however, only LV ejection fraction remained a significant risk 
      predictor on multivariate analysis.
FAU - Grimm, Wolfram
AU  - Grimm W
AD  - Department of Cardiology, Hospital of the Philipps-University of Marburg, 
      Marburg, Germany. Wolfram.Grimm@med.uni-marburg.de
FAU - Schmidt, Georg
AU  - Schmidt G
FAU - Maisch, Bernhard
AU  - Maisch B
FAU - Sharkova, Julia
AU  - Sharkova J
FAU - Muller, Hans-Helge
AU  - Muller HH
FAU - Christ, Michael
AU  - Christ M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Cardiovasc Electrophysiol
JT  - Journal of cardiovascular electrophysiology
JID - 9010756
SB  - IM
MH  - Age Distribution
MH  - Cardiomyopathy, Dilated/*diagnosis/*epidemiology/mortality/surgery
MH  - Comorbidity
MH  - Disease-Free Survival
MH  - Electrocardiography, Ambulatory/*methods
MH  - Germany/epidemiology
MH  - Heart Transplantation/*mortality/statistics & numerical data
MH  - Humans
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Sex Distribution
MH  - Single-Blind Method
MH  - Survival Analysis
MH  - Ventricular Premature Complexes/*diagnosis/*epidemiology/mortality/surgery
EDAT- 2003/08/02 05:00
MHDA- 2004/01/31 05:00
CRDT- 2003/08/02 05:00
PHST- 2003/08/02 05:00 [pubmed]
PHST- 2004/01/31 05:00 [medline]
PHST- 2003/08/02 05:00 [entrez]
AID - 03085 [pii]
AID - 10.1046/j.1540-8167.2003.03085.x [doi]
PST - ppublish
SO  - J Cardiovasc Electrophysiol. 2003 Aug;14(8):819-24. doi: 
      10.1046/j.1540-8167.2003.03085.x.