PMID- 12891232
OWN - NLM
STAT- MEDLINE
DCOM- 20031219
LR  - 20170310
IS  - 0022-9040 (Print)
IS  - 0022-9040 (Linking)
VI  - 43
IP  - 5
DP  - 2003
TI  - [Diagnostic value of heart fatty-acid binding protein in early hospitalized 
      patients with non ST elevation acute coronary syndrome].
PG  - 4-8
AB  - BACKGROUND: Heart fatty-acid-binding protein (FABP) is supposed to be the most 
      sensitive biomarker of myocardial necrosis in patients with Q-wave myocardial 
      infarction (MI) and non-diagnostic ECG during first hours after onset of 
      symptoms. However, diagnostic value of FABP in patients with non-ST elevation 
      acute coronary syndrome (NSTEACS) is not well established. AIM: To elucidate 
      diagnostic value of FABP in patients with NSTEACS hospitalized within time 
      interval considered to be too early for a majority of biochemical tests. MATERIAL 
      AND METHODS: FABP levels were measured by immunofluorometry (HyTest, Finland) in 
      44 patients (26 men, mean age 69+/-8.9 years) at admission within 6 hours (median 
      - 2 h) from onset of index attack of angina and in 6, 12, 24 hours after onset of 
      pain. Cut off FABP level was 12 ng/ml. Serum cardiac troponin I was measured for 
      diagnosis of MI on admission and twice during first 24 hours of hospital stay. 
      Cut off TnI level was 0.4 ng/ml. RESULTS: Acute MI was diagnosed by TnI above cut 
      off in 31 patients (70.5%). There were no new-Q-wave MIs. Average ratio of 
      observed serum FABP level to diagnostic cut off value on admission and in 6, 12, 
      24 hours after onset of pain was higher in patients with MI than in patients with 
      unstable angina (1.01, 1.53, 0.81, 0.66 and 0.78, 0.51, 0.65, 0.56, 
      respectively). The difference was maximally significant in 6 hours after onset of 
      pain (p=0.018). Among patients with MI admission FABP compared with admission TnI 
      more frequently exceeded diagnostic level (in 18 vs 9 patients, respectively, 
      p=0.009). Sensitivity and specificity of admission levels of FABP and TnI for 
      diagnosis of MI were 58 and 85%, 29% and 100%, respectively. CONCLUSION: In 
      patients with NSTEACS during first 6 hours after pain onset FABP compared with 
      TnI has greater sensitivity for detection of MI and sufficient specificity. FABP 
      can be used as additional diagnostic tool for MI detection in early admitted 
      patients with NSTEACS.
FAU - Trifonov, I R
AU  - Trifonov IR
FAU - Katrukha, A G
AU  - Katrukha AG
FAU - Iavelov, I S
AU  - Iavelov IS
FAU - Averkov, O V
AU  - Averkov OV
FAU - Gratsianskii, N A
AU  - Gratsianskii NA
LA  - rus
PT  - Comparative Study
PT  - Journal Article
TT  - Ostryi koronarnyi sindrom bez pod"emov segmenta ST na EKG: diagnosticheskoe 
      znachenie serdechnogo belka, sviazyvaiushchego zhirnye kisloty.
PL  - Russia (Federation)
TA  - Kardiologiia
JT  - Kardiologiia
JID - 0376351
RN  - 0 (Biomarkers)
RN  - 0 (Carrier Proteins)
RN  - 0 (FABP7 protein, human)
RN  - 0 (Fatty Acid-Binding Protein 7)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Troponin I)
RN  - 0 (Tumor Suppressor Proteins)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angina, Unstable/blood/*diagnosis
MH  - Biomarkers
MH  - Carrier Proteins/*blood
MH  - *Electrocardiography
MH  - Fatty Acid-Binding Protein 7
MH  - Fatty Acid-Binding Proteins
MH  - Female
MH  - Fluoroimmunoassay
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/blood/*diagnosis
MH  - *Neoplasm Proteins
MH  - Syndrome
MH  - Time Factors
MH  - Troponin I/blood
MH  - *Tumor Suppressor Proteins
EDAT- 2003/08/02 05:00
MHDA- 2003/12/20 05:00
CRDT- 2003/08/02 05:00
PHST- 2003/08/02 05:00 [pubmed]
PHST- 2003/12/20 05:00 [medline]
PHST- 2003/08/02 05:00 [entrez]
PST - ppublish
SO  - Kardiologiia. 2003;43(5):4-8.