PMID- 12894069
OWN - NLM
STAT- MEDLINE
DCOM- 20040122
LR  - 20190709
IS  - 0190-9622 (Print)
IS  - 0190-9622 (Linking)
VI  - 49
IP  - 2
DP  - 2003 Aug
TI  - Large B-cell lymphoma of the leg: clinical and pathologic characteristics in a 
      North American series.
PG  - 223-8
AB  - BACKGROUND: Large B-cell lymphoma (LBCL) of the leg is an uncommon subset of 
      primary cutaneous B-cell lymphoma that has been described in a series of European 
      patients. OBJECTIVE: Our purpose was to evaluate the clinical manifestation, 
      diagnostic histopathology, immunophenotype, clinical course, and response to 
      treatment of LBCL of the leg. METHODS: We conducted a retrospective case series 
      of 3 patients with primary LBCL of the leg. RESULTS: The 3 elderly patients 
      presented with progressive erythematous nodules on bilateral or unilateral lower 
      extremities. All 3 patients had pre-existing peripheral edema or peripheral 
      vascular disease. Histopathologic examination of the nodules showed dense 
      lymphocytic infiltrates composed predominantly of large dysplastic lymphocytes 
      that marked as B cells (CD20(+)). In 2 cases, the neoplastic cells were BCL-2 
      positive. All patients responded to initial therapy with localized electron beam 
      radiation and chemotherapy but had disease progression. One patient had a 
      complete and durable second response to anti-CD20 monoclonal antibody 
      (rituximab). CONCLUSIONS: The patients described have similar clinical and 
      histopathologic features to those previously described. There may be an 
      association between LBCL and pre-existing lower-extremity vascular disease. 
      Treatment of LBCL is difficult, but 1 patient responded well to systemic 
      anti-CD20 monoclonal antibody.
FAU - Brogan, Beth L
AU  - Brogan BL
AD  - Departments of Medicine, Vanderbilt University Medical School, Nashville, 
      Tennessee 37232-5227, USA.
FAU - Zic, John A
AU  - Zic JA
FAU - Kinney, Marsha C
AU  - Kinney MC
FAU - Hu, Judy Y
AU  - Hu JY
FAU - Hamilton, Katherine S
AU  - Hamilton KS
FAU - Greer, John P
AU  - Greer JP
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antibodies, Monoclonal, Murine-Derived)
RN  - 0 (Antineoplastic Agents)
RN  - 4F4X42SYQ6 (Rituximab)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Monoclonal/therapeutic use
MH  - Antibodies, Monoclonal, Murine-Derived
MH  - Antineoplastic Agents/therapeutic use
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - Leg/pathology
MH  - Lymphoma, B-Cell/drug therapy/*pathology/radiotherapy
MH  - Male
MH  - Retrospective Studies
MH  - Rituximab
MH  - Skin Neoplasms/drug therapy/*pathology/radiotherapy
EDAT- 2003/08/02 05:00
MHDA- 2004/01/24 05:00
CRDT- 2003/08/02 05:00
PHST- 2003/08/02 05:00 [pubmed]
PHST- 2004/01/24 05:00 [medline]
PHST- 2003/08/02 05:00 [entrez]
AID - S0190962203008892 [pii]
AID - 10.1067/s0190-9622(03)00889-2 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 2003 Aug;49(2):223-8. doi: 10.1067/s0190-9622(03)00889-2.