PMID- 1289593
OWN - NLM
STAT- MEDLINE
DCOM- 19930325
LR  - 20190824
IS  - 0021-4868 (Print)
IS  - 0021-4868 (Linking)
VI  - 33
IP  - 5
DP  - 1992 Sep
TI  - Determinants of subsequent late postoperative left ventricular function and 
      reversal of ventricular dilatation after mitral valve replacement for chronic 
      mitral regurgitation.
PG  - 605-18
AB  - We studied 16 patients with chronic mitral regurgitation by echocardiography 
      before, and at 3 weeks, at 6-8 months and at 1-9 years after mitral valve 
      replacement (MVR) to investigate serial changes in left ventricular (LV) function 
      and reversal of ventricular dilatation. All patients at an average of 2.6 years 
      after, and 8 patients before MVR were also studied by echocardiography and, 
      except for 3 patients by measuring plasma catecholamines from the right atrium 
      during bicycle exercise. Before operation, all patients were divided into group A 
      (n = 12) with end-systolic dimension (ESD) < 4 cm and systolic blood pressure 
      (SBP)/ESD > 3, and group B (n = 4) with ESD > 4 cm and SBP/ESD < 3. Maximum 
      reduction in end-diastolic dimension (EDD) occurred at 3 weeks in all patients 
      after MVR (from 60.5 +/- 3.7 to 49.0 +/- 4.5 mm, p < 0.05). ESD was reduced 
      significantly (p < 0.5) only in group A. LV function was normal in group A, but 
      it was depressed in group B at early and late periods after MVR. The slopes of 
      the relationship between the mean velocity of circumferential fiber shortening 
      (Vcf) and plasma norepinephrine (NE) during exercise in all patients in group B 
      decreased along with the depression in LV function. After operation, all patients 
      in group A reached New York Heart Association (NYHA) functional class I, while 
      patients in group B were in NYHA class II. It is concluded that the surgical 
      outcome after MVR for chronic MR will be better if preoperative ESD < 4 cm and 
      SBP/ESD > 3. The relationship between mean Vcf and plasma NE during exercise 
      seemed to be a useful index to evaluate the inotropic reserve of the LV.
FAU - Haque, M E
AU  - Haque ME
AD  - Cardiovascular Division, Tottori University School of Medicine, Yonago, Japan.
FAU - Sasaki, S
AU  - Sasaki S
FAU - Miyakoda, H
AU  - Miyakoda H
FAU - Ishiguro, S
AU  - Ishiguro S
FAU - Kinugawa, T
AU  - Kinugawa T
FAU - Mori, T
AU  - Mori T
FAU - Mashiba, H
AU  - Mashiba H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn Heart J
JT  - Japanese heart journal
JID - 0401175
SB  - IM
MH  - Echocardiography
MH  - Exercise Test
MH  - Female
MH  - Follow-Up Studies
MH  - *Heart Valve Prosthesis
MH  - Humans
MH  - Hypertrophy, Left Ventricular/*diagnostic imaging/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve
MH  - Mitral Valve Insufficiency/epidemiology/*surgery
MH  - Systole/physiology
MH  - Time Factors
MH  - Ventricular Function, Left/*physiology
EDAT- 1992/09/01 00:00
MHDA- 1992/09/01 00:01
CRDT- 1992/09/01 00:00
PHST- 1992/09/01 00:00 [pubmed]
PHST- 1992/09/01 00:01 [medline]
PHST- 1992/09/01 00:00 [entrez]
AID - 10.1536/ihj.33.605 [doi]
PST - ppublish
SO  - Jpn Heart J. 1992 Sep;33(5):605-18. doi: 10.1536/ihj.33.605.