PMID- 12897085
OWN - NLM
STAT- MEDLINE
DCOM- 20031117
LR  - 20190513
IS  - 0931-0509 (Print)
IS  - 0931-0509 (Linking)
VI  - 18
IP  - 8
DP  - 2003 Aug
TI  - Hypoalbuminaemia enhances the renal vasoconstrictor effect of 
      lysophosphatidylcholine.
PG  - 1485-92
AB  - BACKGROUND: Lysophosphatidylcholine (LPC) causes vascular dysfunction in vitro. 
      Lipoprotein LPC is increased in hypoalbuminaemia. Albumin binds LPC and restores 
      LPC-induced abnormalities. We hypothesized that in vivo LPC impairs blood flow 
      more in hypoalbuminaemia than in normoalbuminaemia. METHODS: Increasing 
      concentrations of LPC were infused intra-renally in Nagase analbuminaemic rats 
      (NAR) and Sprague-Dawley rats (controls). RESULTS: Intra-renal LPC (0.1 
      micromol/min, 20 min) reduced renal blood flow (RBF) more (P < 0.01) in NAR (from 
      8.3 +/- 0.3 to 4.0 +/- 1.1) than in controls (from 7.7 +/- 0.7 to 5.8 +/- 0.5 
      ml/min/g kidney). Lysophosphatidylethanolamine had no effect. After stopping LPC, 
      RBF recovery was delayed in NAR [median 90 (range: 70-90) vs 45 min (40-60), P < 
      0.01]. Intravenous bovine serum albumin (BSA) prevented LPC-induced 
      vasoconstriction in both strains. Prolonging LPC for 60 min delayed recovery of 
      RBF. In this setting, intra-renal BSA completely restored RBF in 75 min (30-90), 
      while intra-renal saline over 75 min only resulted in 33 +/- 13% recovery (P < 
      0.01). Baseline renal LPC content was unchanged in NAR. However, intra-renal LPC 
      infusion doubled renal LPC content in NAR, but had no effect in controls. 
      CONCLUSIONS: In NAR, baseline RBF and renal LPC content are normal. However, 
      exposure of NAR to LPC results in much more vasoconstriction and accumulation of 
      LPC than in normoalbuminaemia. Addition of albumin prevents and restores 
      LPC-induced vasoconstriction.
FAU - Vuong, Thi Danh
AU  - Vuong TD
AD  - Department of Nephrology and Hypertension, University Medical Center, Utrecht, 
      The Netherlands.
FAU - Braam, Branko
AU  - Braam B
FAU - Willekes-Koolschijn, Nel
AU  - Willekes-Koolschijn N
FAU - Boer, Peter
AU  - Boer P
FAU - Koomans, Hein A
AU  - Koomans HA
FAU - Joles, Jaap A
AU  - Joles JA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European 
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
RN  - 0 (Lysophosphatidylcholines)
RN  - 0 (Vasoconstrictor Agents)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Hypoalbuminemia/*physiopathology
MH  - Kidney/drug effects/*physiopathology
MH  - Lysophosphatidylcholines/*pharmacology
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Rats, Sprague-Dawley
MH  - Regional Blood Flow/drug effects
MH  - Vasoconstrictor Agents/*pharmacology
EDAT- 2003/08/05 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/08/05 05:00
PHST- 2003/08/05 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/08/05 05:00 [entrez]
AID - 10.1093/ndt/gfg238 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2003 Aug;18(8):1485-92. doi: 10.1093/ndt/gfg238.