PMID- 12897814
OWN - NLM
STAT- MEDLINE
DCOM- 20040322
LR  - 20111117
IS  - 0008-4212 (Print)
IS  - 0008-4212 (Linking)
VI  - 81
IP  - 7
DP  - 2003 Jul
TI  - Effects and consequences of nerve injury on the electrical properties of sensory 
      neurons.
PG  - 663-82
AB  - Nociceptive pain alerts the body to potential or actual tissue damage. By 
      contrast, neuropathic or "noninflammatory" pain, which results from injury to the 
      nervous system, serves no useful purpose. It typically continues for years after 
      the original injury has healed. Sciatic nerve lesions can invoke chronic 
      neuropathic pain that is accompanied by persistent, spontaneous activity in 
      primary afferent fibers. This activity, which reflects changes in the properties 
      and functional expression of Na+, K+, and Ca2+ channels, initiates a further 
      increase in the excitability of second-order sensory neurons in the dorsal horn. 
      This change persists for many weeks. The source of origin of the pain thus moves 
      from the peripheral to the central nervous system. We hypothesize that this 
      centralization of pain involves the inappropriate release of peptidergic 
      neuromodulators from primary afferent fibers. Peptides such as substance P, 
      neuropeptide Y (NPY), calcitonin-gene-related peptide (CGRP), and brain-derived 
      neurotrophic factor (BDNF) may promote enduring changes in excitability as a 
      consequence of neurotrophic actions on ion channel expression in the dorsal horn. 
      Findings that form the basis of this hypothesis are reviewed. Study of the 
      neurotrophic control of ion channel expression by spinal peptides may thus 
      provide new insights into the etiology of neuropathic pain.
FAU - Abdulla, Fuad A
AU  - Abdulla FA
AD  - Department of Physical Therapy, School of Allied Health Sciences, Hashemite 
      University, Zarqa, Jordan.
FAU - Moran, Timothy D
AU  - Moran TD
FAU - Balasubramanyan, Sridhar
AU  - Balasubramanyan S
FAU - Smith, Peter A
AU  - Smith PA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Canada
TA  - Can J Physiol Pharmacol
JT  - Canadian journal of physiology and pharmacology
JID - 0372712
RN  - 0 (Ion Channels)
SB  - IM
MH  - Action Potentials/*physiology
MH  - Animals
MH  - Ganglia, Spinal/*injuries/*physiology
MH  - Humans
MH  - Ion Channels/physiology
MH  - Neurons, Afferent/*physiology
MH  - Peripheral Nerve Injuries
MH  - Peripheral Nerves/physiology
RF  - 200
EDAT- 2003/08/05 05:00
MHDA- 2004/03/23 05:00
CRDT- 2003/08/05 05:00
PHST- 2003/08/05 05:00 [pubmed]
PHST- 2004/03/23 05:00 [medline]
PHST- 2003/08/05 05:00 [entrez]
AID - y03-064 [pii]
AID - 10.1139/y03-064 [doi]
PST - ppublish
SO  - Can J Physiol Pharmacol. 2003 Jul;81(7):663-82. doi: 10.1139/y03-064.