PMID- 12898229
OWN - NLM
STAT- MEDLINE
DCOM- 20040122
LR  - 20181113
IS  - 0932-0113 (Print)
IS  - 0932-0113 (Linking)
VI  - 91
IP  - 2
DP  - 2003 Sep
TI  - Cytokine responses in mice infected with Clonorchis sinensis.
PG  - 87-93
AB  - FVB and BALB/c mice show different morbidity, development of Clonorchis sinensis, 
      and pathological changes following C. sinensis infection. FVB mice are 
      susceptible and BALB/c mice are relatively more resistant to C. sinensis 
      infection. To investigate the relationship between cytokine reaction and 
      susceptibility to C. sinensis infection in FVB and BALB/c mice, we described both 
      the patterns and kinetics of Th1 cytokines and Th2 cytokines in spleen cell 
      culture. Interleukin (IL)-4 and IL-10 cytokine production in the culture 
      supernatants of the concanavalin-A-stimulated spleen cells increased at 2-3 weeks 
      post-infection in both strains. IL-5 production increased between 2 and 5 weeks 
      post-infection in both strains, and reached a peak level at 2 weeks 
      post-infection in BALB/c mice and 4 weeks post-infection in FVB mice. In 
      contrast, gamma interferon (IFN-gamma) production decreased between 2 and 4 weeks 
      in both strains. IL-2 production increased slightly in BALB/c mice following 
      infection, but was unchanged in FVB mice. IL-4 production over preinfection 
      levels was significantly higher in FVB mice, whereas IFN-gamma, IL-2, and IL-10 
      production were significantly higher in BALB/c mice. The levels of serum 
      immunoglobulin E (IgE) and blood eosinophils in both mouse strains significantly 
      increased between 3 and 6 weeks postinfection. Serum IgE levels were 
      significantly higher in FVB mice than in BALB/c mice. The results of this study 
      suggest that susceptibility to C. sinensis infection is associated with Th2 
      cytokine production, especially IL-4 which is predominant in relatively 
      susceptible FVB mice.
FAU - Choi, Yang Kyu
AU  - Choi YK
AD  - Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.
FAU - Yoon, Byung Il
AU  - Yoon BI
FAU - Won, Young Suk
AU  - Won YS
FAU - Lee, Chul Ho
AU  - Lee CH
FAU - Hyun, Byung Hwa
AU  - Hyun BH
FAU - Kim, Hyoung Chin
AU  - Kim HC
FAU - Oh, Goo Taeg
AU  - Oh GT
FAU - Kim, Dae Yong
AU  - Kim DY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20030729
PL  - Germany
TA  - Parasitol Res
JT  - Parasitology research
JID - 8703571
RN  - 0 (Antibodies, Helminth)
RN  - 0 (Cytokines)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Antibodies, Helminth/blood
MH  - Cells, Cultured
MH  - Clonorchiasis/*immunology/parasitology/pathology
MH  - Clonorchis sinensis/growth & development/immunology/*pathogenicity
MH  - Cytokines/*biosynthesis
MH  - Disease Susceptibility
MH  - Eosinophils/immunology
MH  - Female
MH  - Immunoglobulin E/blood
MH  - Liver/parasitology/pathology
MH  - Mice
MH  - Spleen/cytology
MH  - Th1 Cells/immunology
MH  - Th2 Cells/immunology
EDAT- 2003/08/05 05:00
MHDA- 2004/01/24 05:00
CRDT- 2003/08/05 05:00
PHST- 2003/04/07 00:00 [received]
PHST- 2003/05/27 00:00 [accepted]
PHST- 2003/08/05 05:00 [pubmed]
PHST- 2004/01/24 05:00 [medline]
PHST- 2003/08/05 05:00 [entrez]
AID - 10.1007/s00436-003-0934-2 [doi]
PST - ppublish
SO  - Parasitol Res. 2003 Sep;91(2):87-93. doi: 10.1007/s00436-003-0934-2. Epub 2003 
      Jul 29.