PMID- 12898603
OWN - NLM
STAT- MEDLINE
DCOM- 20031006
LR  - 20071115
IS  - 0022-3417 (Print)
IS  - 0022-3417 (Linking)
VI  - 200
IP  - 5
DP  - 2003 Aug
TI  - Typical genomic imbalances in primary MALT lymphoma of the orbit.
PG  - 656-60
AB  - Primary orbital non-Hodgkin lymphoma is a mucosa-associated lymphoid tissue 
      (MALT)-type extranodal marginal zone lymphoma. Little information is available on 
      its genome as conventional cytogenetics is limited by scarce biopsy material, 
      while fluorescence in situ hybridization (FISH) explores only selected regions. 
      Comparative genomic hybridization (CGH) performs full genomic analysis and is 
      applicable to different sources of DNA, such as fresh and frozen cells, as well 
      as paraffin-embedded tissues. In this study, CGH was used to analyse primary MALT 
      lymphoma of the orbit. Aneuploidy was identified in six of the ten cases studied. 
      Gains (19) were more frequent than losses (5). The most frequent duplications 
      involved chromosome 3 (common region at 3q24-qter), as expected in marginal zone 
      lymphoma, and chromosome 6 (common region at 6p21.1-21.3), which is typical of an 
      orbital location. Other chromosome gains were found at 1p, 7, 8q, 9q, 12, 13, 17, 
      18, 19, 22, and X. Losses were located at 1q, 6q, 9q, 11q, and 13q. Two cases 
      showed isolated duplications of chromosome 6p or 9q. Isolated imbalances were 
      found only in tumours affecting the conjunctiva. Complex aneuploidies were 
      observed in lymphoma of the retro-orbital tissue. In summary, CGH in orbital MALT 
      lymphoma provided new insights into typical genomic imbalances and underlying 
      pathogenetic mechanisms.
CI  - Copyright 2003 John Wiley & Sons, Ltd.
FAU - Matteucci, Caterina
AU  - Matteucci C
AD  - Haematology and Bone Marrow Transplantation Unit, Policlinico Monteluce, 
      University of Perugia, via Brunamonti, 06123 Perugia, Italy. crimecux@unipg.it
FAU - Galieni, Piero
AU  - Galieni P
FAU - Leoncini, Lorenzo
AU  - Leoncini L
FAU - Lazzi, Stefano
AU  - Lazzi S
FAU - Lauria, Francesco
AU  - Lauria F
FAU - Polito, Ennio
AU  - Polito E
FAU - Martelli, Massimo F
AU  - Martelli MF
FAU - Mecucci, Cristina
AU  - Mecucci C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Pathol
JT  - The Journal of pathology
JID - 0204634
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 6/genetics
MH  - Chromosomes, Human, Pair 9/genetics
MH  - DNA, Neoplasm/genetics
MH  - Female
MH  - Humans
MH  - Lymphoma, B-Cell, Marginal Zone/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Nucleic Acid Hybridization/methods
MH  - Orbital Neoplasms/*genetics/pathology
EDAT- 2003/08/05 05:00
MHDA- 2003/10/08 05:00
CRDT- 2003/08/05 05:00
PHST- 2003/08/05 05:00 [pubmed]
PHST- 2003/10/08 05:00 [medline]
PHST- 2003/08/05 05:00 [entrez]
AID - 10.1002/path.1386 [doi]
PST - ppublish
SO  - J Pathol. 2003 Aug;200(5):656-60. doi: 10.1002/path.1386.