PMID- 12899980
OWN - NLM
STAT- MEDLINE
DCOM- 20040413
LR  - 20190815
IS  - 0731-7085 (Print)
IS  - 0731-7085 (Linking)
VI  - 32
IP  - 4-5
DP  - 2003 Aug 8
TI  - Capillary electrophoresis in analysis of veterinary drugs.
PG  - 937-47
AB  - Antibiotics are extensively applied in veterinary medicine for the treatment of 
      various bacterial infections. Because of their use in food producing animals, the 
      risk of occurrence of unwanted residues in edible products exists. To ensure 
      human food safety, The European Union has defined maximum residue limits (MRLs) 
      for veterinary drug residues in food products. Analytical methods need to be 
      developed to confirm the presence of antibiotics at the MRL level. A capillary 
      electrophoresis (CE) method with UV detection is proposed for the quantitative 
      determination of residues from poultry and porcine tissues. Eight of the most 
      frequently used antibiotics and nifursol, which routinely used as poultry 
      coccidiostat, were analysed. CE technique permitted analysing substances to be 
      separated from muscle, liver, kidney and skin with fat after a simple extraction 
      with acetonitrile or ethyl acetate under basic conditions. Proposed method is 
      capable to identify drug residues in tissues at level below 20 microg/kg.
FAU - Kowalski, P
AU  - Kowalski P
AD  - Medical University of Gdansk, Hallera 107, PL-80-416 Gdansk, Poland.
FAU - Oledzka, I
AU  - Oledzka I
FAU - Lamparczyk, H
AU  - Lamparczyk H
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Pharm Biomed Anal
JT  - Journal of pharmaceutical and biomedical analysis
JID - 8309336
RN  - 0 (Veterinary Drugs)
SB  - IM
MH  - Animals
MH  - Electrophoresis, Capillary/methods
MH  - Poultry
MH  - Swine
MH  - Technology, Pharmaceutical/*methods
MH  - Tissue Distribution/physiology
MH  - Veterinary Drugs/*analysis/*metabolism
EDAT- 2003/08/06 05:00
MHDA- 2004/04/14 05:00
CRDT- 2003/08/06 05:00
PHST- 2003/08/06 05:00 [pubmed]
PHST- 2004/04/14 05:00 [medline]
PHST- 2003/08/06 05:00 [entrez]
AID - S073170850300195X [pii]
AID - 10.1016/s0731-7085(03)00195-x [doi]
PST - ppublish
SO  - J Pharm Biomed Anal. 2003 Aug 8;32(4-5):937-47. doi: 
      10.1016/s0731-7085(03)00195-x.