PMID- 12903412
OWN - NLM
STAT- MEDLINE
DCOM- 20040625
LR  - 20061115
IS  - 1000-503X (Print)
IS  - 1000-503X (Linking)
VI  - 22
IP  - 6
DP  - 2000 Dec
TI  - [Detection of hyperdiploid in malignant cells in fine-needle aspirates from lung 
      cancer by fluorescence in situ hybridization].
PG  - 589-91
AB  - OBJECTIVE: To study the numerical abnormality of chromosomes in malignant cells 
      in fine-needle aspirates from lung cancer by fluorescence in situ hybridization 
      (FISH). METHODS: 30 fine-needle aspirates from lung cancer (4 from lung tissues, 
      26 from lymph nodes) were detected by FISH with the centromere DNA probes for 
      chromosome 7, 11, 17 and X. RESULTS: In 27 positive fine-needle aspirates the 
      rates of hyperdiploid in chromosome 7, X, 17, and 11 were 81.5% (22/27), 77.8% 
      (21/27), 70.4% (19/27) and 63.0% (17/27), respectively. In 3 negative fine-needle 
      aspirates, the number of chromosomes was normal. CONCLUSIONS: (1) Interphase 
      cytogenetic cells analysis of fine-needle aspirates by FISH is feasible and 
      simple; (2) Hyperdiploid in malignant cells in fine-needle aspirates from lung 
      cancer can be used as a biomarker for benign and malignant cells.
FAU - Jia, D
AU  - Jia D
AD  - Department of Clinical Cytology, Cancer Institute, CAMS and PUMC, Beijing 100021, 
      China.
FAU - Zhang, Z
AU  - Zhang Z
FAU - Liu, S
AU  - Liu S
FAU - Cheng, S
AU  - Cheng S
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao
JT  - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
JID - 8006230
RN  - 0 (DNA Probes)
SB  - IM
MH  - Biopsy, Needle
MH  - Chromosomes, Human/*genetics
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Chromosomes, Human, Pair 17/genetics
MH  - Chromosomes, Human, Pair 7/genetics
MH  - Chromosomes, Human, X/genetics
MH  - DNA Probes
MH  - *Diploidy
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Lung Neoplasms/diagnosis/*genetics/*pathology
MH  - Male
EDAT- 2003/08/09 05:00
MHDA- 2004/06/26 05:00
CRDT- 2003/08/09 05:00
PHST- 2003/08/09 05:00 [pubmed]
PHST- 2004/06/26 05:00 [medline]
PHST- 2003/08/09 05:00 [entrez]
PST - ppublish
SO  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2000 Dec;22(6):589-91.