PMID- 12903433
OWN - NLM
STAT- MEDLINE
DCOM- 20040625
LR  - 20061115
IS  - 1000-503X (Print)
IS  - 1000-503X (Linking)
VI  - 22
IP  - 5
DP  - 2000 Oct
TI  - [Insulin-like growth factor-I(IGF-I), and its binding protein-3 (IGFBP-3) 
      correlated with fetal development].
PG  - 476-8
AB  - OBJECTIVE: To study the relations between IGF-I, IGFBP-3 and human fetal growth. 
      METHODS: The blood samples of maternal serum (MS) and umbilical cord serum (UCS) 
      from 81 cases with singleton term pregnancy including 38 cases of normal 
      pregnancy (NP), 20 cases of gestational diabetic mellitus (GDM), 23 cases of 
      macrosomia of non-diabetic pregnancy (MNDP) were examined for IGF-I and IGFBP-3 
      levels by immunoassay kit from DSL, USA. RESULTS: IGF-I in MS of NP and MNDP 
      showed a positive correlation with birth weight (BW) (r = 0.653 and r = 0.640 
      respectively, both P < 0.01). IGF-I of MS in MNDP was higher than that in NP (P < 
      0.05). IGF-I of MS and UCS in GDM were higher than that in NP (P < 0.05). IGF-I 
      and IGFBP-3 of UCS in these three groups were significantly lower than that of MS 
      (P < 0.001). CONCLUSION: Detection of IGF-I in MS can assess fetal intra-uterus 
      growth, birth weight and has certain value of predicting macrosomia. IGF-I and 
      IGFBP-3 play important roles for human fetal growth.
FAU - Qian, M
AU  - Qian M
AD  - Department of Gynecology and Obstetrics, PUMC Hospital, CAMS and PUMC, Beijing 
      100730, China.
FAU - Fan, Q
AU  - Fan Q
FAU - Bian, X
AU  - Bian X
FAU - Zhu, L
AU  - Zhu L
FAU - Lang, J
AU  - Lang J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao
JT  - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
JID - 8006230
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adult
MH  - Birth Weight
MH  - Diabetes, Gestational/blood
MH  - *Embryonic and Fetal Development
MH  - Female
MH  - Fetal Blood/*chemistry
MH  - Fetal Macrosomia/diagnosis
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/*blood
MH  - Insulin-Like Growth Factor I/*analysis
MH  - Pregnancy
MH  - Radioimmunoassay
EDAT- 2003/08/09 05:00
MHDA- 2004/06/26 05:00
CRDT- 2003/08/09 05:00
PHST- 2003/08/09 05:00 [pubmed]
PHST- 2004/06/26 05:00 [medline]
PHST- 2003/08/09 05:00 [entrez]
PST - ppublish
SO  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2000 Oct;22(5):476-8.