PMID- 12908943
OWN - NLM
STAT- MEDLINE
DCOM- 20040702
LR  - 20190513
IS  - 0146-4760 (Print)
IS  - 0146-4760 (Linking)
VI  - 27
IP  - 5
DP  - 2003 Jul-Aug
TI  - Usefulness of sweat testing for the detection of MDMA after a single-dose 
      administration.
PG  - 294-303
AB  - Nine healthy male subjects and recreational users of 
      3,4-methylenedioxymethamphetamine (MDMA) participated in a study aimed to assess 
      the usefulness of sweat testing for the detection of MDMA after a single 100-mg 
      dose. Sweat was collected for up to 24 h with the PharmChek sweat patches from 
      which drugs were eluted and then analyzed by immunoassay and gas 
      chromatography-mass spectrometry using deuterated internal standards. The 
      usefulness of a rapid onsite test, the Drugwipe immunochemical strip test, was 
      also assessed. In the sweat patches, MDMA was detected as early as 1.5 h after 
      consumption and peaked at 24 h. Intersubject variability was large; peak MDMA 
      concentrations for the same dose varied in magnitude 30-fold. MDMA concentrations 
      ranged between 3.2 and 1326.1 ng/patch. Only traces of the minor metabolite 
      3,4-methylenedioxyamphetamine were detected. In all subjects, the onsite test 
      with the Drugwipe was positive at 1.5 h (peak time of MDMA plasma concentration). 
      However, few false-negative results (18%) appeared in the first 6 h after 
      administration. Both sweat patch testing and the onsite sweat strip test may find 
      useful application for noninvasive monitoring of MDMA abuse in sweat.
FAU - Pichini, Simona
AU  - Pichini S
AD  - Istituto Superiore di Sanita, Roma, Italy.
FAU - Navarro, Monica
AU  - Navarro M
FAU - Pacifici, Roberta
AU  - Pacifici R
FAU - Zuccaro, Piergiorgio
AU  - Zuccaro P
FAU - Ortuno, Jordi
AU  - Ortuno J
FAU - Farre, Magi
AU  - Farre M
FAU - Roset, Pere Nolasc
AU  - Roset PN
FAU - Segura, Jordi
AU  - Segura J
FAU - de la Torre, Rafael
AU  - de la Torre R
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Anal Toxicol
JT  - Journal of analytical toxicology
JID - 7705085
RN  - 0 (Hallucinogens)
RN  - 0 (Reagent Strips)
RN  - 117652-28-5 (4-hydroxy-3-methoxymethamphetamine)
RN  - 44RAL3456C (Methamphetamine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analysis
MH  - Adult
MH  - Cross-Over Studies
MH  - Double-Blind Method
MH  - Feasibility Studies
MH  - Gas Chromatography-Mass Spectrometry
MH  - Hallucinogens/*analysis/pharmacokinetics
MH  - Humans
MH  - Immunoassay
MH  - Male
MH  - Methamphetamine/analogs & derivatives/chemistry
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*analysis/pharmacokinetics
MH  - Reagent Strips
MH  - Substance Abuse Detection/instrumentation/*methods
MH  - Sweat/*chemistry/metabolism
MH  - Time Factors
EDAT- 2003/08/12 05:00
MHDA- 2004/07/03 05:00
CRDT- 2003/08/12 05:00
PHST- 2003/08/12 05:00 [pubmed]
PHST- 2004/07/03 05:00 [medline]
PHST- 2003/08/12 05:00 [entrez]
AID - 10.1093/jat/27.5.294 [doi]
PST - ppublish
SO  - J Anal Toxicol. 2003 Jul-Aug;27(5):294-303. doi: 10.1093/jat/27.5.294.