PMID- 12910109
OWN - NLM
STAT- MEDLINE
DCOM- 20031209
LR  - 20181130
IS  - 0761-8425 (Print)
IS  - 0761-8425 (Linking)
VI  - 20
IP  - 3 Pt 1
DP  - 2003 Jun
TI  - [EGF-R expression correlation between biopsy and surgical specimens of lung 
      carcinoma].
PG  - 347-53
AB  - INTRODUCTION: Most of the time, biological parameters are evaluated on tissues 
      obtained on surgical samples of the primary tumour. New approaches in non small 
      cell lung cancer (NSCLC) treatment consist to administer neoadjuvant chemotherapy 
      or anti-EGF-R (epidermal growth factor receptor) drug. METHODS: We assessed the 
      expression of EGF-R by immunohistochemistry on biopsy samples and on the paired 
      resected tumours in 27 patients. RESULTS: The mean percentage of EGF-R positive 
      neoplastic cells was 11% in surgical specimens compared to 28% in biopsy 
      specimens (p=0.02) although a good correlation (R=0.67; p=0.0001) between 
      biopsies and surgical specimens was observed. Furthermore, the positivity 
      (cut-off > 1% cells) rate was not statistically different between biopsies (55%) 
      and tumours (48%) (p=0.63). In term of positivity rate, we found 85% concordant 
      results between biopsies and resected tumours, 4% false negative and 11% false 
      positive on biopsies in comparison with the resected tumours. The positive and 
      negative predictive value of the biopsies were respectively 80% and 92%. 
      CONCLUSIONS: The evaluation of EGF-R by immunohistochemistry on biopsies may 
      provide reliable information about non small cell lung cancer EGF-R status.
FAU - Meert, A-P
AU  - Meert AP
AD  - FNRS (Fonds National de la Recherche Scientifique), Institut Jules Boerdet, 
      Bruxelles, Belgique. ap.meert@bordet.be
FAU - Martin, B
AU  - Martin B
FAU - Verdebout, J-M
AU  - Verdebout JM
FAU - Paesmans, M
AU  - Paesmans M
FAU - Lothaire, P
AU  - Lothaire P
FAU - Bosschaerts, T
AU  - Bosschaerts T
FAU - Ninane, V
AU  - Ninane V
FAU - Sculier, J-P
AU  - Sculier JP
LA  - fre
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Correlation entre l'expression d'EGF-R dans les biopsies et les pieces 
      chirurgicales des cancers bronchiques.
PL  - France
TA  - Rev Mal Respir
JT  - Revue des maladies respiratoires
JID - 8408032
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
CIN - Rev Mal Respir. 2003 Jun;20(3 Pt 1):315-7. PMID: 12910102
MH  - Adenocarcinoma/metabolism/*pathology/surgery
MH  - Adult
MH  - Aged
MH  - Biopsy
MH  - Carcinoma, Squamous Cell/metabolism/*pathology/surgery
MH  - ErbB Receptors/*metabolism
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Lung Neoplasms/metabolism/*pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Sensitivity and Specificity
EDAT- 2003/08/12 05:00
MHDA- 2003/12/11 05:00
CRDT- 2003/08/12 05:00
PHST- 2003/08/12 05:00 [pubmed]
PHST- 2003/12/11 05:00 [medline]
PHST- 2003/08/12 05:00 [entrez]
AID - MDOI-RMR-06-2003-20-3-0761-8425-101019-ART10 [pii]
PST - ppublish
SO  - Rev Mal Respir. 2003 Jun;20(3 Pt 1):347-53.