PMID- 12911427
OWN - NLM
STAT- MEDLINE
DCOM- 20031224
LR  - 20191210
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 58
IP  - 9
DP  - 2003 Sep
TI  - Diagnostic value of scratch-chamber test, skin prick test, histamine release and 
      specific IgE in birch-allergic patients with oral allergy syndrome to apple.
PG  - 950-3
AB  - BACKGROUND: The aim of the study was to examine the diagnostic value of skin 
      prick test (SPT), scratch-chamber test (SCT), histamine release (HR) and specific 
      immunoglobulin E (IgE) in birch-allergic patients with oral allergy syndrome to 
      apple. METHODS: Ten birch-allergic patients with oral allergy syndrome to apple 
      and 10 control subjects were included. All were tested with SPT, SCT, HR and 
      specific IgE [CAP, Pharmacia, Sweden and Magic Lite (ML), ALK-ABELLO, Denmark]. 
      RESULTS: The SPT with apple, acetone extract of apple (A72) and commercial apple 
      extract showed sensitivities of 0.80, 0.90 and 0.10, respectively. The SCT with 
      the same extracts showed sensitivities of 0.30, 0.50 and 0.20, respectively. The 
      sensitivity of specific IgE to apple were 0.90 (CAP) and 0.10 (ML). The 
      sensitivity of the HR test was 90% (A72), and 25% using the commercial extract. 
      CONCLUSION: The SPT and HR test with apple and A72 showed a good diagnostic value 
      with a sensitivity of more than 70% and a specificity of 100%. The SCT showed a 
      poor sensitivity to apple, A72 and commercial apple extract. The ML test was not 
      suitable in detecting specific IgE to apple compared with the CAP test. In daily 
      practice a detailed case history about symptoms of oral allergy syndrome combined 
      with a SPT with fresh apple peel or A72 will be useful.
FAU - Osterballe, M
AU  - Osterballe M
AD  - Allergy Center, Department of Dermatology, Odense University Hospital, Sdr 
      Boulevard 29, DK 5000 Odense C, Denmark.
FAU - Scheller, R
AU  - Scheller R
FAU - Stahl Skov, P
AU  - Stahl Skov P
FAU - Andersen, K E
AU  - Andersen KE
FAU - Bindslev-Jensen, C
AU  - Bindslev-Jensen C
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - Allergy. 2004 Aug;59(8):888. PMID: 15230824
MH  - Adult
MH  - Food Hypersensitivity/*diagnosis
MH  - *Histamine Release
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Malus/*adverse effects
MH  - Middle Aged
MH  - *Skin Tests
EDAT- 2003/08/13 05:00
MHDA- 2003/12/25 05:00
CRDT- 2003/08/13 05:00
PHST- 2003/08/13 05:00 [pubmed]
PHST- 2003/12/25 05:00 [medline]
PHST- 2003/08/13 05:00 [entrez]
AID - 272 [pii]
AID - 10.1034/j.1398-9995.2003.00272.x [doi]
PST - ppublish
SO  - Allergy. 2003 Sep;58(9):950-3. doi: 10.1034/j.1398-9995.2003.00272.x.