PMID- 12914591
OWN - NLM
STAT- MEDLINE
DCOM- 20040106
LR  - 20191026
IS  - 0036-5564 (Print)
IS  - 0036-5564 (Linking)
VI  - 44
IP  - 3
DP  - 2003 Jul
TI  - Bicuculline infusion into the accessory olfactory bulb facilitates the induction 
      of maternal behavior in rats.
PG  - 273-7
AB  - The GABAA antagonist bicuculline, intracranially infused into the accessory 
      olfactory bulb (AOB), facilitated the expression of maternal behavior (MB) in 
      virgin Wistar female rats. Behavioral effects were observed 24 hours after 
      infusion and were injection dependent. Pheromonal stimuli, generated by the pups, 
      are thought to exert an inhibitory effect on vomeronasal nuclei involved in MB in 
      virgin rats. The present study investigated the possibility that a decrement in 
      AOB output, resulting from long-term compensatory synaptic changes to chronic 
      bicuculline infusion, would facilitate the expression of MB. The implications of 
      our findings for the mechanisms involved in the induction of MB and the maternal 
      experience effect are discussed.
FAU - Carretero, M I
AU  - Carretero MI
AD  - Dept. de Psicobiologia, Univ. Nacional de Educacion a Distancia, Madrid, Spain 
      Area 11, IMSALUD, Madrid, Spain.
FAU - Segovia, S
AU  - Segovia S
FAU - Gomez, F
AU  - Gomez F
FAU - Del Cerro, M C R
AU  - Del Cerro MC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand J Psychol
JT  - Scandinavian journal of psychology
JID - 0404510
RN  - 0 (Convulsants)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - Animals
MH  - Bicuculline/administration & dosage/*pharmacology
MH  - Convulsants/administration & dosage/*pharmacology
MH  - Female
MH  - *Infusion Pumps
MH  - Maternal Behavior/*drug effects
MH  - Olfactory Bulb/*drug effects
MH  - Rats
MH  - Rats, Wistar
EDAT- 2003/08/14 05:00
MHDA- 2004/01/07 05:00
CRDT- 2003/08/14 05:00
PHST- 2003/08/14 05:00 [pubmed]
PHST- 2004/01/07 05:00 [medline]
PHST- 2003/08/14 05:00 [entrez]
AID - 345 [pii]
AID - 10.1111/1467-9450.00345 [doi]
PST - ppublish
SO  - Scand J Psychol. 2003 Jul;44(3):273-7. doi: 10.1111/1467-9450.00345.