PMID- 12914971
OWN - NLM
STAT- MEDLINE
DCOM- 20031128
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 983
IP  - 1-2
DP  - 2003 Sep 5
TI  - Exercise-induced changes in hippocampal brain-derived neurotrophic factor and 
      neurotrophin-3: effects of rat strain.
PG  - 108-14
AB  - We tested the hypothesis that exercise-induced changes in hippocampal 
      brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) differ among 
      rat strains exhibiting a range of voluntary wheel running activity. Four strains 
      (Sprague-Dawley, Brown Norway, Dark Agouti and PVG) were given access to running 
      wheels (1 or 7 nights). Over 7 nights, the average distance run per night was 
      higher in PVG versus other strains, and higher in Brown Norway versus 
      Sprague-Dawley rats. Hippocampal BDNF concentrations in sedentary rats were 
      higher in PVG versus Sprague-Dawley rats. When data from all strains were 
      combined, BDNF levels increased with 7 nights of wheel running and were 
      positively correlated to the previous night distance run. Sedentary hippocampal 
      NT-3 levels were not different between rat strains, but decreased with 7 nights 
      of wheel access; NT-3 was negatively correlated with previous night distance run. 
      There were no differences between strains in the correlation between distance run 
      and BDNF or NT-3 levels. Although exercise decreases hippocampal NT-3, strain 
      does not alter NT-3 levels. In contrast, BDNF levels increase with exercise and 
      basal levels differ between strains, possibly due to strain differences in 
      spontaneous activity.
FAU - Johnson, Rebecca A
AU  - Johnson RA
AD  - Department of Comparative Biosciences, University of Wisconsin, 2015 Linden 
      Drive, Madison, WI 53706, USA. pipob@svm.vetmed.wisc.edu
FAU - Mitchell, Gordon S
AU  - Mitchell GS
LA  - eng
GR  - HL03874/HL/NHLBI NIH HHS/United States
GR  - HL36780/HL/NHLBI NIH HHS/United States
GR  - HL65383/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotrophin 3)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Hippocampus/*physiology
MH  - Male
MH  - Neurotrophin 3/*metabolism
MH  - Physical Exertion/*physiology
MH  - Rats
MH  - Rats, Inbred BN
MH  - Rats, Inbred Strains
MH  - Rats, Sprague-Dawley
MH  - Running/physiology
MH  - Species Specificity
EDAT- 2003/08/14 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/08/14 05:00
PHST- 2003/08/14 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/08/14 05:00 [entrez]
AID - S0006899303030397 [pii]
AID - 10.1016/s0006-8993(03)03039-7 [doi]
PST - ppublish
SO  - Brain Res. 2003 Sep 5;983(1-2):108-14. doi: 10.1016/s0006-8993(03)03039-7.