PMID- 12915552
OWN - NLM
STAT- MEDLINE
DCOM- 20030924
LR  - 20220311
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 77
IP  - 17
DP  - 2003 Sep
TI  - Passive immunization with neutralizing antibodies interrupts the mouse mammary 
      tumor virus life cycle.
PG  - 9369-77
AB  - Mouse mammary tumor virus (MMTV) infects the host via mucosal surfaces and 
      exploits the host immune system for systemic spread and chronic infection. We 
      have tested a neutralizing rat monoclonal antibody specific for the retroviral 
      envelope glycoprotein gp52 for its efficiency in preventing acute and chronic 
      mucosal and systemic infection. The antibody completely inhibits the superantigen 
      response and chronic viral infection following systemic or nasal infection. 
      Surprisingly however, the antibody only partially inhibits the early infection of 
      antigen-presenting cells in the draining lymph node. Despite this initially 
      inefficient protection from infection, superantigen-specific B- and T-cell 
      responses and systemic viral spread are abolished, leading to complete clearance 
      of the retroviral infection and hence interruption of the viral life cycle. In 
      conclusion, systemic neutralizing monoclonal antibodies can provide an efficient 
      protection against chronic retroviral amplification and persistence.
FAU - Mpandi, M
AU  - Mpandi M
AD  - Swiss Institute for Experimental Cancer Research. Institute of Biochemistry, 
      University of Lausanne, Switzerland.
FAU - Otten, L A
AU  - Otten LA
FAU - Lavanchy, C
AU  - Lavanchy C
FAU - Acha-Orbea, H
AU  - Acha-Orbea H
FAU - Finke, D
AU  - Finke D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigens, Viral, Tumor)
RN  - 0 (DNA, Viral)
RN  - 0 (glycoprotein 52 antigen, Mouse mammary tumor virus)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/administration & dosage
MH  - Antibodies, Viral/administration & dosage
MH  - Antigens, Viral, Tumor/genetics/immunology
MH  - B-Lymphocytes/immunology/pathology
MH  - Base Sequence
MH  - Cell Differentiation
MH  - DNA, Viral/genetics
MH  - Female
MH  - Immunity, Mucosal
MH  - Immunization, Passive
MH  - Mammary Neoplasms, Experimental/immunology/prevention & control
MH  - Mammary Tumor Virus, Mouse/genetics/*growth & development/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neutralization Tests
MH  - Rats
MH  - Rats, Inbred Lew
MH  - Retroviridae Infections/immunology/prevention & control
MH  - Tumor Virus Infections/immunology/prevention & control
PMC - PMC187390
EDAT- 2003/08/14 05:00
MHDA- 2003/09/25 05:00
PMCR- 2003/09/01
CRDT- 2003/08/14 05:00
PHST- 2003/08/14 05:00 [pubmed]
PHST- 2003/09/25 05:00 [medline]
PHST- 2003/08/14 05:00 [entrez]
PHST- 2003/09/01 00:00 [pmc-release]
AID - 0337 [pii]
AID - 10.1128/jvi.77.17.9369-9377.2003 [doi]
PST - ppublish
SO  - J Virol. 2003 Sep;77(17):9369-77. doi: 10.1128/jvi.77.17.9369-9377.2003.