PMID- 12917077
OWN - NLM
STAT- MEDLINE
DCOM- 20031020
LR  - 20220408
IS  - 1530-891X (Print)
IS  - 1530-891X (Linking)
VI  - 9
IP  - 2
DP  - 2003 Mar-Apr
TI  - Severe reversible dilated cardiomyopathy and hyperthyroidism: case report and 
      review of the literature.
PG  - 140-6
AB  - OBJECTIVE: To describe a case of a 46-year-old woman with Graves' disease and 
      reversible low-output congestive heart failure and present a comparative analysis 
      of 23 similar cases reported in the literature. METHODS: A detailed case report 
      is presented. In addition, a review of the pertinent literature published between 
      1960 and 2002 was performed to identify similar cases of dilated cardiomyopathy 
      and thyrotoxicosis and to assess the findings in these patients. RESULTS: A 
      46-year-old woman without primary heart disease was admitted to the hospital with 
      Graves' thyrotoxicosis and severe low-output congestive heart failure. Her left 
      ventricular ejection fraction (LVEF) at the time of initial assessment was less 
      than 20%, and her condition was categorized as New York Heart Association (NYHA) 
      functional class III. Nineteen months after she was treated for hyperthyroidism, 
      her LVEF was 49% and her status was NYHA class I. A severe hypotensive episode 
      occurred when b-adrenergic blockade therapy was initiated. The group of 23 
      similar cases from the literature plus our currently described patient had a mean 
      age of 45 years, a male-to-female ratio of 1:1.2, Graves' disease as the 
      principal cause, and LVEF improvement from 29% to 58%. CONCLUSION: Dilated 
      cardiomyopathy is an unusual manifestation of hyperthyroidism with unclear cause. 
      Clinicians should be aware of this entity because it is treatable and hypotension 
      can occur if b-adrenergic blockade treatment is initiated.
FAU - Boccalandro, Cristina
AU  - Boccalandro C
AD  - Division of Endocrinology and Metabolism, University of Texas at Houston, 
      Houston, Texas, USA.
FAU - Boccalandro, Fernando
AU  - Boccalandro F
FAU - Orlander, Philip
AU  - Orlander P
FAU - Wei, Chik Fong
AU  - Wei CF
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Endocr Pract
JT  - Endocrine practice : official journal of the American College of Endocrinology 
      and the American Association of Clinical Endocrinologists
JID - 9607439
RN  - 0 (Adrenergic beta-Antagonists)
SB  - IM
MH  - Adrenergic beta-Antagonists/adverse effects
MH  - Cardiac Output
MH  - Cardiomyopathy, Dilated/*complications/drug therapy/physiopathology
MH  - Female
MH  - Humans
MH  - Hyperthyroidism/*complications
MH  - Hypotension/chemically induced/physiopathology/therapy
MH  - Middle Aged
RF  - 58
EDAT- 2003/08/15 05:00
MHDA- 2003/10/21 05:00
CRDT- 2003/08/15 05:00
PHST- 2003/08/15 05:00 [pubmed]
PHST- 2003/10/21 05:00 [medline]
PHST- 2003/08/15 05:00 [entrez]
AID - S1530-891X(20)40918-8 [pii]
AID - 10.4158/EP.9.2.140 [doi]
PST - ppublish
SO  - Endocr Pract. 2003 Mar-Apr;9(2):140-6. doi: 10.4158/EP.9.2.140.