PMID- 12918070
OWN - NLM
STAT- MEDLINE
DCOM- 20031117
LR  - 20221207
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 106
IP  - 6
DP  - 2003 Oct 10
TI  - Human papillomavirus type 16 E6 variants and HLA class II alleles among Japanese 
      women with cervical cancer.
PG  - 919-22
AB  - The enhanced oncogenicity of particular human papillomavirus type 16 (HPV16) E6 
      variants is population-dependent, implying the involvement of additional genetic 
      cofactors. This study was designed to investigate the association between E6 
      variants and human leukocyte antigen (HLA) polymorphism within a Japanese 
      population. Fifty-seven women with HPV16-positive cervical cancer were analyzed 
      for E6 sequence variation and its relationship to HLA class II alleles. Compared 
      with local controls (n = 138) and published controls (n = 916), DRB1*1501 and 
      DQB1*0602 frequencies were significantly increased among patients with HPV16 E6 
      prototype (n = 11). Additionally, DRB1*1502 was positively associated with a 
      particular E6 variant designated D25E (n = 25), although we could not find a 
      significant association between HLA class II alleles and L83V variants (n = 16). 
      Our observations suggest that a specific match between E6 variant proteins and 
      HLA types may contribute to HPV16-related cervical carcinogenesis.
CI  - Copyright 2003 Wiley-Liss, Inc.
FAU - Matsumoto, Koji
AU  - Matsumoto K
AD  - Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan. 
      matsumok@mui.biglobe.ne.jp
FAU - Yasugi, Toshiharu
AU  - Yasugi T
FAU - Nakagawa, Shunsuke
AU  - Nakagawa S
FAU - Okubo, Mitsuo
AU  - Okubo M
FAU - Hirata, Ranko
AU  - Hirata R
FAU - Maeda, Hiroo
AU  - Maeda H
FAU - Yoshikawa, Hiroyuki
AU  - Yoshikawa H
FAU - Taketani, Yuji
AU  - Taketani Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (DNA, Viral)
RN  - 0 (E6 protein, Human papillomavirus type 16)
RN  - 0 (Oncogene Proteins, Viral)
RN  - 0 (Repressor Proteins)
SB  - IM
MH  - Carcinoma in Situ/epidemiology/metabolism/virology
MH  - Case-Control Studies
MH  - DNA, Viral/genetics
MH  - Female
MH  - *Genes, MHC Class II
MH  - Genotype
MH  - Humans
MH  - Japan/epidemiology
MH  - Mutation/*genetics
MH  - Neoplasm Invasiveness
MH  - Oncogene Proteins, Viral/classification/*genetics
MH  - Papillomaviridae/classification/*genetics
MH  - Papillomavirus Infections/complications/virology
MH  - *Polymorphism, Genetic
MH  - *Repressor Proteins
MH  - Risk Factors
MH  - T-Lymphocytes, Cytotoxic/immunology
MH  - Tumor Virus Infections/complications/virology
MH  - Uterine Cervical Neoplasms/epidemiology/metabolism/*virology
MH  - Uterine Cervical Dysplasia/epidemiology/metabolism/*virology
EDAT- 2003/08/15 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/08/15 05:00
PHST- 2003/08/15 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/08/15 05:00 [entrez]
AID - 10.1002/ijc.11332 [doi]
PST - ppublish
SO  - Int J Cancer. 2003 Oct 10;106(6):919-22. doi: 10.1002/ijc.11332.