PMID- 12919239
OWN - NLM
STAT- MEDLINE
DCOM- 20031020
LR  - 20190709
IS  - 0002-8614 (Print)
IS  - 0002-8614 (Linking)
VI  - 51
IP  - 9
DP  - 2003 Sep
TI  - Associations between polymorphisms of the high-affinity immunoglobulin E receptor 
      and late-onset airflow obstruction in older populations.
PG  - 1265-9
AB  - OBJECTIVES: To test the hypothesis that genetic polymorphisms in the beta subunit 
      of the high-affinity immunoglobulin E (IgE) receptor are associated with 
      late-onset airflow obstruction. DESIGN: Case-control candidate gene association 
      study. SETTING: Department of Medicine for the Elderly and Respiratory Medicine 
      in three teaching hospitals in Leicester and Manchester, United Kingdom. 
      PARTICIPANTS: Cases with late-onset airflow obstruction with age-, sex-, and 
      geographically matched controls. MEASUREMENTS: Subjects were genotyped for two 
      polymorphisms of the beta subunit of the high-affinity IgE receptor (RsaI intron 
      2 and RsaI exon 7). The association between the polymorphisms and phenotypes was 
      examined using contingency tables and linear regression models. RESULTS: Two 
      hundred eighty-three cases and 144 controls were genotyped. RsaI exon 7 AA was 
      associated with eczema (odds ratio (OR)=2.27, 95% confidence interval 
      (CI)=1.17-4.38, P=.015). No other associations were found. Total serum IgE levels 
      were significantly higher in cases than controls (adjusted OR for high/low 
      IgE=2.56, 95% CI=1.53-4.28, P<.001). CONCLUSION: Serum IgE levels, but not the 
      high-affinity IgE receptor polymorphisms, were associated with late-onset airflow 
      obstruction, suggesting that interaction between environmental and genetic 
      factors controlling serum IgE levels and disease pathogenesis may differ between 
      early- and late-onset airflow obstruction phenotypes.
FAU - Ruse, Charlotte E
AU  - Ruse CE
AD  - Institute for Lung Health, University of Leicester, Leicester, United Kingdom. 
      charlotteruse@lycos.co.uk
FAU - Hill, Maureen C
AU  - Hill MC
FAU - Burton, Paul R
AU  - Burton PR
FAU - Connolly, Martin J
AU  - Connolly MJ
FAU - Wardlaw, Andrew J
AU  - Wardlaw AJ
FAU - Parker, Stuart G
AU  - Parker SG
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Geriatr Soc
JT  - Journal of the American Geriatrics Society
JID - 7503062
RN  - 0 (Receptors, IgE)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Asthma/blood/diagnosis/genetics/physiopathology
MH  - Confidence Intervals
MH  - Eczema/genetics
MH  - Female
MH  - Forced Expiratory Volume
MH  - Genotype
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Linear Models
MH  - Lung Diseases, Obstructive/blood/diagnosis/*genetics/physiopathology
MH  - Male
MH  - Phenotype
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Pulmonary Disease, Chronic Obstructive/blood/diagnosis/genetics/physiopathology
MH  - Receptors, IgE/*genetics
MH  - Sex Factors
MH  - Spirometry
MH  - Time Factors
EDAT- 2003/08/16 05:00
MHDA- 2003/10/21 05:00
CRDT- 2003/08/16 05:00
PHST- 2003/08/16 05:00 [pubmed]
PHST- 2003/10/21 05:00 [medline]
PHST- 2003/08/16 05:00 [entrez]
AID - 51411 [pii]
AID - 10.1046/j.1532-5415.2003.51411.x [doi]
PST - ppublish
SO  - J Am Geriatr Soc. 2003 Sep;51(9):1265-9. doi: 10.1046/j.1532-5415.2003.51411.x.