PMID- 12920440
OWN - NLM
STAT- MEDLINE
DCOM- 20030916
LR  - 20190717
IS  - 0002-9629 (Print)
IS  - 0002-9629 (Linking)
VI  - 326
IP  - 2
DP  - 2003 Aug
TI  - Hyponatremia associated with 3,4-methylenedioxymethylamphetamine ("Ecstasy") 
      abuse.
PG  - 89-93
AB  - We present a case of acute, symptomatic hyponatremia in a young woman that 
      developed after use of 3,4-methylenedioxymethylamphetamine (MDMA), more commonly 
      known as "ecstasy." The patient was treated with 5% saline and had complete 
      recovery. The pathogenesis of MDMA-associated hyponatremia involves excessive 
      water intake and inappropriately elevated antidiuretic hormone (ADH) levels. It 
      seems that young, premenopausal women are at particularly high risk for the 
      development of severe, symptomatic hyponatremia after use of this drug. Review of 
      the literature revealed 4 fatal outcomes from MDMA-associated hyponatremia. All 
      were women and all died from cerebellar tonsillar herniation. We suggest that 
      acute hyponatremia that develops after MDMA use may be a life-threatening 
      condition. Recent recommendation that MDMA users should drink large volumes of 
      water may not be appropriate.
FAU - Budisavljevic, Milos N
AU  - Budisavljevic MN
AD  - Nephrology Division, Division of Pulmonary and Critical Care Medicine, Medical 
      University of South Carolina, 171 Ashley Avenue, Charleston, NC 29425, USA. 
      budisamn@musc.edu
FAU - Stewart, Lisa
AU  - Stewart L
FAU - Sahn, Steven A
AU  - Sahn SA
FAU - Ploth, David W
AU  - Ploth DW
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
RN  - 11000-17-2 (Vasopressins)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adolescent
MH  - Female
MH  - Humans
MH  - Hyponatremia/blood/drug therapy/*etiology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects/blood
MH  - Sodium Chloride/therapeutic use
MH  - Substance-Related Disorders/blood/*complications/drug therapy
MH  - Vasopressins/blood
RF  - 37
EDAT- 2003/08/16 05:00
MHDA- 2003/09/17 05:00
CRDT- 2003/08/16 05:00
PHST- 2003/08/16 05:00 [pubmed]
PHST- 2003/09/17 05:00 [medline]
PHST- 2003/08/16 05:00 [entrez]
AID - S0002-9629(15)34237-3 [pii]
AID - 10.1097/00000441-200308000-00006 [doi]
PST - ppublish
SO  - Am J Med Sci. 2003 Aug;326(2):89-93. doi: 10.1097/00000441-200308000-00006.