PMID- 12921346
OWN - NLM
STAT- MEDLINE
DCOM- 20030926
LR  - 20061115
IS  - 1050-9631 (Print)
IS  - 1050-9631 (Linking)
VI  - 13
IP  - 5
DP  - 2003
TI  - Neuropeptide Y delays hippocampal kindling in the rat.
PG  - 557-60
AB  - Chronic intrahippocampal infusion of the neurotrophin brain-derived neurotrophic 
      factor (BDNF) has been shown to delay kindling epileptogenesis in the rat and 
      several lines of evidence suggest that neuropeptide Y could mediate these 
      inhibitory effects. Chronic infusion of BDNF leads to a sustained overexpression 
      of neuropeptide Y in the hippocampus, which follows a time course similar to that 
      of the suppressive effects of BDNF on kindling. In vivo, acute applications of 
      neuropeptide Y or agonists of its receptors exert anticonvulsant properties, 
      especially on seizures of hippocampal origin. In this study, we examined how 
      chronic infusion of this neuropeptide in the hippocampus affected kindling 
      epileptogenesis. A 7-day continuous infusion of neuropeptide Y in the hippocampus 
      delayed the progression of hippocampal kindling in the rat, whereas 
      anti-neuropeptide Y immunoglobulins had an aggravating effect. These results show 
      that neuropeptide Y exerts anti-epileptogenic properties on seizures originating 
      within the hippocampus and lend support to the hypothesis that BDNF delays 
      kindling at least in part through upregulation of this neuropeptide. They also 
      suggest that the seizure-induced upregulation of neuropeptide Y constitutes an 
      endogenous mechanism counteracting excessive hippocampal excitability.
FAU - Reibel, Sophie
AU  - Reibel S
AD  - INSERM U398, Faculte de Medecine, Strasbourg Cedex, France. Reibel@lyon.inserm.fr
FAU - Benmaamar, Ramla
AU  - Benmaamar R
FAU - Le, Bich Thuy
AU  - Le BT
FAU - Larmet, Yves
AU  - Larmet Y
FAU - Kalra, Satya P
AU  - Kalra SP
FAU - Marescaux, Christian
AU  - Marescaux C
FAU - Depaulis, Antoine
AU  - Depaulis A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hippocampus
JT  - Hippocampus
JID - 9108167
RN  - 0 (Antibodies)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuropeptide Y)
SB  - IM
MH  - Animals
MH  - Antibodies/pharmacology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Disease Models, Animal
MH  - Epilepsy/drug therapy/*metabolism/physiopathology
MH  - Hippocampus/drug effects/*metabolism/physiopathology
MH  - Kindling, Neurologic/drug effects/*physiology
MH  - Male
MH  - Neurons/drug effects/metabolism
MH  - Neuropeptide Y/antagonists & inhibitors/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Reaction Time/drug effects/physiology
MH  - Synaptic Transmission/drug effects/physiology
MH  - Up-Regulation/drug effects/physiology
EDAT- 2003/08/19 05:00
MHDA- 2003/09/27 05:00
CRDT- 2003/08/19 05:00
PHST- 2003/08/19 05:00 [pubmed]
PHST- 2003/09/27 05:00 [medline]
PHST- 2003/08/19 05:00 [entrez]
AID - 10.1002/hipo.10110 [doi]
PST - ppublish
SO  - Hippocampus. 2003;13(5):557-60. doi: 10.1002/hipo.10110.