PMID- 12921913
OWN - NLM
STAT- MEDLINE
DCOM- 20031023
LR  - 20220310
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 27
IP  - 5
DP  - 2003 Aug
TI  - Immunohistochemical study of brain-derived neurotrophic factor and its receptor, 
      TrkB, in the hippocampal formation of schizophrenic brains.
PG  - 801-7
AB  - Recently, the pathogenesis of schizophrenia has been investigated from the 
      perspective of neurodevelopmental dysfunction theory. On the other hand, it has 
      been indicated that neurotrophic factors, such as nerve growth factors, 
      brain-derived neurotrophic factor (BDNF), and neurotrophin-3, are significantly 
      involved in the development and functional differences of central nervous system 
      (CNS). Some reports proposed that the dysfunction of these factors could explain 
      the pathogenesis of schizophrenia possibly. In this study, the authors 
      investigated immunohistochemically the distribution and/or morphology of BDNF and 
      TrkB, its peculiar receptor, in the hippocampal formation of schizophrenic brain. 
      As a result, BDNF-positive pyramidal cells in the CA2 and neurons in the CA3 and 
      the field of the CA4 were intensely stained compared to those of normal control. 
      Staining of TrkB-positive neurons showed a signet-ring like shape in the 
      hippocampus of normal control brains. Such figures were not observed on staining 
      of those neurons from schizophrenic brains. In the control cases, 
      TrkB-immunopositive varicose fibers were frequently seen. Those observed 
      differences between schizophrenic and normal cases may indicate the existence of 
      dysfunction of BDNF and TrkB in schizophrenic brain, and this dysfunction may be 
      one of the factors involved in the pathogenesis of schizophrenia.
FAU - Iritani, Shuji
AU  - Iritani S
AD  - Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, 2-1-1 
      Kamikitazawa, Setagaya, Tokyo 156-0057, Japan. 
      iritani@matsuzawa-hp.metro.tokyo.jp
FAU - Niizato, Kazuhiro
AU  - Niizato K
FAU - Nawa, Hiroyuki
AU  - Nawa H
FAU - Ikeda, Kenji
AU  - Ikeda K
FAU - Emson, Piers C
AU  - Emson PC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain-Derived Neurotrophic Factor/*analysis/metabolism
MH  - Female
MH  - Hippocampus/*chemistry/metabolism/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Receptor, trkB/*analysis/metabolism
MH  - Schizophrenia/metabolism/pathology
EDAT- 2003/08/19 05:00
MHDA- 2003/10/24 05:00
CRDT- 2003/08/19 05:00
PHST- 2003/08/19 05:00 [pubmed]
PHST- 2003/10/24 05:00 [medline]
PHST- 2003/08/19 05:00 [entrez]
AID - S0278-5846(03)00112-X [pii]
AID - 10.1016/S0278-5846(03)00112-X [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2003 Aug;27(5):801-7. doi: 
      10.1016/S0278-5846(03)00112-X.