PMID- 12927058
OWN - NLM
STAT- MEDLINE
DCOM- 20040305
LR  - 20200225
IS  - 1582-1838 (Print)
IS  - 1582-4934 (Electronic)
IS  - 1582-1838 (Linking)
VI  - 7
IP  - 2
DP  - 2003 Apr-Jun
TI  - Adhesion inhibition "in vitro" by heparin derivatives correlates with their 
      activity on angiogenesis in mice.
PG  - 187-91
AB  - Heparin (HEP) play an important role in angiogenesis. Inhibition of matrix 
      degrading enzymes and binding to adhesion molecules are some of the interaction 
      mechanism. The bleeding risk and the need of parenteral administration, restrict 
      the therapeutic use of HEP as angiogenesis modulator; presently derivatives, with 
      different pharmacokinetic and anticoagulant properties, are available. In this 
      study the "in vitro" anti-adhesion activity, tested with PMNs and endothelial 
      cells, was compared with the effect on angiogenesis, evaluated in Matrigel 
      implanted mice. Some HEP derivatives, with low anticoagulant activity, showed a 
      significant angiogenesis inhibition. A positive correlation between adhesion 
      inhibition in vitro and anti-angiogenesis effect in vivo was found suggesting 
      that the interaction with adhesion molecules by HEP derivatives play a relevant 
      role in the angiogenesis control.
FAU - Rizea Savu, Simona
AU  - Rizea Savu S
AD  - National Institute for Pharmaceutical Chemistry, 112 Vitan Rd., Bucharest, 
      Romania. Dreispharma@aol.com
FAU - Silvestro, L
AU  - Silvestro L
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Cell Mol Med
JT  - Journal of cellular and molecular medicine
JID - 101083777
RN  - 0 (Drug Combinations)
RN  - 0 (Laminin)
RN  - 0 (Proteoglycans)
RN  - 119978-18-6 (matrigel)
RN  - 9005-49-6 (Heparin)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - Cell Adhesion/*physiology
MH  - Cell Line
MH  - Collagen/metabolism
MH  - Drug Combinations
MH  - Heparin/administration & dosage/analogs & derivatives/*metabolism
MH  - Humans
MH  - In Vitro Techniques
MH  - Laminin/metabolism
MH  - Male
MH  - Mice
MH  - *Neovascularization, Physiologic
MH  - Neutrophils/cytology/metabolism
MH  - Proteoglycans/metabolism
PMC - PMC6740101
EDAT- 2003/08/21 05:00
MHDA- 2004/03/06 05:00
PMCR- 2003/04/01
CRDT- 2003/08/21 05:00
PHST- 2003/08/21 05:00 [pubmed]
PHST- 2004/03/06 05:00 [medline]
PHST- 2003/08/21 05:00 [entrez]
PHST- 2003/04/01 00:00 [pmc-release]
AID - 007.002.10 [pii]
AID - JCMM187 [pii]
AID - 10.1111/j.1582-4934.2003.tb00218.x [doi]
PST - ppublish
SO  - J Cell Mol Med. 2003 Apr-Jun;7(2):187-91. doi: 
      10.1111/j.1582-4934.2003.tb00218.x.