PMID- 12927207
OWN - NLM
STAT- MEDLINE
DCOM- 20031110
LR  - 20190712
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 120
IP  - 4
DP  - 2003
TI  - Induction of tyrosine kinase receptor b by retinoic acid allows brain-derived 
      neurotrophic factor-induced amyloid precursor protein gene expression in human 
      SH-SY5Y neuroblastoma cells.
PG  - 1019-26
AB  - Retinoic acid (RA) is a potent regulator of morphogenesis, growth and cell 
      differentiation. Incubation with RA causes arrest of proliferation and neurite 
      extension in SH-SY5Y cells, a neuroblastoma cell line of human origin. In these 
      cells, RA regulates the expression of the beta-amyloid precursor protein. The 
      retinoid increases the levels of intracellular and secreted forms of APP (amyloid 
      precursor protein), APP-mRNA levels and the activity of the APP promoter in 
      transient transfection studies. These responses require long periods of 
      exposition to the ligand, thus suggesting a nondirect effect of the RA receptors 
      on the APP gene. Also in these cells, RA induces the expression of TrkB, the 
      tyrosine kinase receptor for brain-derived neurotrophic factor (BDNF), and 4 days 
      of pretreatment with retinoic acid confers BDNF responsiveness to the APP 
      promoter.
FAU - Ruiz-Leon, Y
AU  - Ruiz-Leon Y
AD  - Consejo Superior de Investigaciones, Instituto de Investigaciones Biomedicas 
      Cientificas, Arturo Duperier, 4, 28029, Madrid, Spain.
FAU - Pascual, A
AU  - Pascual A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 10028-17-8 (Tritium)
RN  - 5688UTC01R (Tretinoin)
RN  - EC 2.3.1.28 (Chloramphenicol O-Acetyltransferase)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - VC2W18DGKR (Thymidine)
SB  - IM
MH  - Amyloid beta-Protein Precursor/*metabolism
MH  - Autoradiography
MH  - Blotting, Northern
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cell Differentiation/drug effects
MH  - Cell Division/drug effects
MH  - Chloramphenicol O-Acetyltransferase/metabolism
MH  - Drug Interactions
MH  - Gene Expression Regulation/*drug effects
MH  - Humans
MH  - Neuroblastoma/*genetics
MH  - RNA, Messenger/metabolism
MH  - Receptor Protein-Tyrosine Kinases/*biosynthesis
MH  - Receptor, trkB/genetics/metabolism
MH  - Thymidine/metabolism
MH  - Time Factors
MH  - Transfection/methods
MH  - Tretinoin/*pharmacology
MH  - Tritium/metabolism
MH  - Tumor Cells, Cultured
EDAT- 2003/08/21 05:00
MHDA- 2003/11/11 05:00
CRDT- 2003/08/21 05:00
PHST- 2003/08/21 05:00 [pubmed]
PHST- 2003/11/11 05:00 [medline]
PHST- 2003/08/21 05:00 [entrez]
AID - S0306452203003919 [pii]
AID - 10.1016/s0306-4522(03)00391-9 [doi]
PST - ppublish
SO  - Neuroscience. 2003;120(4):1019-26. doi: 10.1016/s0306-4522(03)00391-9.