PMID- 12928863
OWN - NLM
STAT- MEDLINE
DCOM- 20031031
LR  - 20181113
IS  - 0340-6717 (Print)
IS  - 0340-6717 (Linking)
VI  - 113
IP  - 5
DP  - 2003 Oct
TI  - Sex differences in heritability of sensitization to Blomia tropicalis in asthma 
      using regression of offspring on midparent (ROMP) methods.
PG  - 437-46
AB  - A genetic basis for asthma- and atopy-related quantitative traits, such as 
      allergen-specific immunoglobulin E (IgE) levels, has been suggested by the 
      observed familial aggregation of these traits in temperate climates. Less 
      information is available for tropical climates, where different allergens may 
      predominate. Sensitivity to the mite Blomia tropicalis is related to asthma in 
      tropical climates, but heritability of B. tropicalis sensitivity and the impact 
      of age, sex, and other environmental covariates on heritability have not been 
      widely explored. Total and specific IgE levels were measured by 
      immunochemiluminescent assay in 481 members of 29 Barbadian families (comprised 
      of 340 parent-offspring trios or pairs) ascertained through two asthmatic 
      siblings. Trait heritability was estimated using regression of offspring on 
      mid-parent (ROMP) and pairwise correlation analysis of unadjusted IgE levels and 
      on residual values after adjustment for covariates. Heritability of IgE levels to 
      the major antigen of B. tropicalis (Blo t M) estimated by ROMP in 180 complete 
      parent-offspring trios was 0.56. Heritability was consistently greater for male 
      offspring than for female offspring. Similar sex-specific patterns were observed 
      for specific IgE to Dermatophagoides pteronyssinus and total IgE levels and were 
      relatively unaffected by adjustment for covariates. Pairwise correlational 
      analyses of specific and total IgE levels showed similar results. Moderate 
      heritability of Blo t M IgE levels was detected in these Barbadian families and 
      was greater for sons than daughters. Adjustment for covariates had minimal 
      impact. This suggests that future investigations of genetic determinants of IgE 
      levels should include approaches that allow for potential sex differences in 
      their expression.
FAU - Manolio, Teri A
AU  - Manolio TA
AD  - Division of Epidemiology and Clinical Applications, National Heart, Lung,and 
      Blood Institute, 6701 Rockledge Drive, Rm. 8160, Bethesda, MD 20892-7934, USA. 
      manolio@nih.gov
FAU - Barnes, Kathleen C
AU  - Barnes KC
FAU - Beaty, Terri H
AU  - Beaty TH
FAU - Levett, Paul N
AU  - Levett PN
FAU - Naidu, Raana P
AU  - Naidu RP
FAU - Wilson, Alexander F
AU  - Wilson AF
LA  - eng
GR  - 1 P41 RR03655/RR/NCRR NIH HHS/United States
GR  - 1 R01 AI20059/AI/NIAID NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20030820
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Acari/*immunology
MH  - Adult
MH  - Animals
MH  - Asthma/*genetics/*immunology
MH  - Barbados
MH  - Female
MH  - Housing
MH  - Humans
MH  - Immunization
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Mites/*immunology
MH  - Nuclear Family
MH  - Sex Characteristics
MH  - Tropical Climate
EDAT- 2003/08/21 05:00
MHDA- 2003/11/01 05:00
CRDT- 2003/08/21 05:00
PHST- 2003/04/18 00:00 [received]
PHST- 2003/07/10 00:00 [accepted]
PHST- 2003/08/21 05:00 [pubmed]
PHST- 2003/11/01 05:00 [medline]
PHST- 2003/08/21 05:00 [entrez]
AID - 10.1007/s00439-003-1005-6 [doi]
PST - ppublish
SO  - Hum Genet. 2003 Oct;113(5):437-46. doi: 10.1007/s00439-003-1005-6. Epub 2003 Aug 
      20.