PMID- 12930493
OWN - NLM
STAT- MEDLINE
DCOM- 20040129
LR  - 20190726
IS  - 0147-8389 (Print)
IS  - 0147-8389 (Linking)
VI  - 26
IP  - 9
DP  - 2003 Sep
TI  - Global repolarization sequence of the right atrium: monphasic action potential 
      mapping in health pigs.
PG  - 1803-8
AB  - The aim of the study was to explore the global sequence of atrial repolarization 
      and its correlation to that of activation. Endocardial monophasic action 
      potentials (MAPs) were sequentially recorded from 51 +/- 14 sites in the right 
      atrium of ten healthy pigs using the CARTO electroanatomic mapping system. Local 
      activation time (AT), MAP duration, and 90% repolarization time (RT) were 
      obtained, and from these data, color coded three-dimensional maps of AT and RT 
      sequences and spatial distribution of MAP duration were reconstructed. The 
      results of the study were: (1) An activation sequence was recognizable in all 
      maps, starting from the posterosuperior wall and ending in the posteroinferior 
      wall near the tricuspid annulus. (2) The repolarization sequence was also 
      recognizable in all maps, and mainly followed the sequence of activation. (3) A 
      significant positive correlation between the RT and AT was observed in all maps 
      with an average r value being 0.571 +/- 0.159 (P < 0.01 - 0.0001), suggesting 
      that progressively later AT associates with progressively longer RT. (4) No 
      consistent correlation between the MAP duration and AT was found. In conclusion, 
      repolarization gradients exist over the atrial endocardium in healthy pigs. The 
      repolarization sequence follows the same sequence as the activation, suggesting 
      that the spatiotemporal pattern of activation is an important determinant of the 
      characteristics of the repolarization sequence.
FAU - Li, Zhen
AU  - Li Z
AD  - Department of Cardiology, University Hospital, Lund, Sweden.
FAU - Hertervig, Eva
AU  - Hertervig E
FAU - Kongstad, Ole
AU  - Kongstad O
FAU - Holm, Magnus
AU  - Holm M
FAU - Grins, Edgars
AU  - Grins E
FAU - Olsson, S Bertil
AU  - Olsson SB
FAU - Yuan, Shiwen
AU  - Yuan S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
MH  - Action Potentials/physiology
MH  - Animals
MH  - *Atrial Function, Right
MH  - Cardiac Catheterization
MH  - *Electrophysiologic Techniques, Cardiac
MH  - Heart Conduction System/physiology
MH  - Swine
EDAT- 2003/08/22 05:00
MHDA- 2004/01/30 05:00
CRDT- 2003/08/22 05:00
PHST- 2003/08/22 05:00 [pubmed]
PHST- 2004/01/30 05:00 [medline]
PHST- 2003/08/22 05:00 [entrez]
AID - 273 [pii]
AID - 10.1046/j.1460-9592.2003.t01-1-00273.x [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2003 Sep;26(9):1803-8. doi: 
      10.1046/j.1460-9592.2003.t01-1-00273.x.