PMID- 12931039
OWN - NLM
STAT- MEDLINE
DCOM- 20040324
LR  - 20221207
IS  - 0301-0163 (Print)
IS  - 0301-0163 (Linking)
VI  - 60
IP  - 3
DP  - 2003
TI  - Presentation and 5-year follow-up of type 2 diabetes mellitus in African-American 
      and Caribbean-Hispanic adolescents.
PG  - 121-6
AB  - OBJECTIVE: We report the presentation and 5-year follow-up of 89 African-American 
      (AA) and Caribbean-Hispanic (CH) youths with type 2 diabetes mellitus (T2DM) 
      followed at the Montefiore Medical Center, Bronx, N.Y., USA, from 1990 to 2000. 
      METHODS: The medical records of 89 patients with T2DM diagnosed between 1990 and 
      2000 were reviewed. RESULTS: Over a 10-year period, the number of pediatric 
      patients less than 18 years of age diagnosed with T2DM at the Montefiore Medical 
      Center increased tenfold. At presentation, the mean age was 14 +/- 2.3 years, the 
      mean body mass index (BMI) was 34.4 +/- 9 kg/m(2), the female/male ratio was 
      1.6:1, and all these patients were pubertal. Acanthosis nigricans was present in 
      89% of the patients, polyuria and polydipsia occurred in 48%, weight loss 
      occurred in 22%, and nearly 30% of the patients were asymptomatic at diagnosis. 
      Diabetic ketoacidosis occurred in 5 patients. By 5 years after diagnosis, 45% of 
      the patients were able to maintain an HgbA1C <7% with oral medications (metformin 
      and/or glipizide); 18% required insulin (<0.4 U/kg/day) in addition to oral 
      medications, and 37% did not require any medication. The mean insulin level, BMI 
      and HgbA1C at the time of diagnosis did not predict treatment requirements for 3 
      years after diagnosis. CONCLUSIONS: Because the incidence of T2DM is increasing 
      in adolescents, the natural history and optimal therapy for adolescents with T2DM 
      need to be established.
CI  - Copyright 2003 S. Karger AG, Basel
FAU - Grinstein, Gabriela
AU  - Grinstein G
AD  - Department of Pediatrics, Division of Pediatric Endocrinology, Albert Einstein 
      College of Medicine, Bronx, NY, USA.
FAU - Muzumdar, Radhika
AU  - Muzumdar R
FAU - Aponte, Leonor
AU  - Aponte L
FAU - Vuguin, Patricia
AU  - Vuguin P
FAU - Saenger, Paul
AU  - Saenger P
FAU - DiMartino-Nardi, Joan
AU  - DiMartino-Nardi J
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Horm Res
JT  - Hormone research
JID - 0366126
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Adolescent
MH  - *Black or African American
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - Caribbean Region/ethnology
MH  - Child
MH  - Diabetes Mellitus/epidemiology
MH  - Diabetes Mellitus, Type 2/complications/*drug therapy/*ethnology/pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Glycated Hemoglobin/metabolism
MH  - *Hispanic or Latino
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - Insulin/blood/therapeutic use
MH  - Male
MH  - Metformin/therapeutic use
MH  - Obesity
MH  - Prevalence
EDAT- 2003/08/22 05:00
MHDA- 2004/03/25 05:00
CRDT- 2003/08/22 05:00
PHST- 2002/06/17 00:00 [received]
PHST- 2003/05/20 00:00 [accepted]
PHST- 2003/08/22 05:00 [pubmed]
PHST- 2004/03/25 05:00 [medline]
PHST- 2003/08/22 05:00 [entrez]
AID - 72523 [pii]
AID - 10.1159/000072523 [doi]
PST - ppublish
SO  - Horm Res. 2003;60(3):121-6. doi: 10.1159/000072523.