PMID- 12931213
OWN - NLM
STAT- MEDLINE
DCOM- 20040205
LR  - 20171116
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 17
IP  - 11
DP  - 2003 Nov
TI  - Translocations t(11;18)(q21;q21) and t(14;18)(q32;q21) are the main chromosomal 
      abnormalities involving MLT/MALT1 in MALT lymphomas.
PG  - 2225-9
AB  - The recently discovered MLT/MALT1 gene is fused with the API2 gene in the 
      t(11;18)(q21;q21), which characterizes about one-third of MALT lymphomas. In 
      order to screen for variant translocations and amplifications of MLT/MALT1, we 
      have developed a novel, undirected two-color interphase fluorescence in situ 
      hybridization (FISH) assay with two PAC clones flanking MLT/MALT1. This assay was 
      applied to 108 marginal zone B-cell lymphomas (MZBCLs), including 72 extranodal 
      MALT lymphomas, 17 nodal, and 19 splenic MZBCL. In 19 MALT lymphomas (26%), but 
      in none of the nodal or splenic MZBCL, separated hybridization signals of the 
      MLT/MALT1 flanking probes, were found. Further FISH analyses showed that 12 of 
      these 19 cases displayed the classical t(11;18) and the remaining seven cases 
      revealed the novel t(14;18)(q32;q21), involving the MLT/MALT1 and IGH genes. The 
      frequency at which these translocations occurred varied significantly with the 
      primary location of disease. The t(11;18) was mainly detected in gastrointestinal 
      MALT lymphomas, whereas the t(14;18) occurred in MALT lymphomas of the parotid 
      gland and the conjunctiva. Amplification of MLT/MALT1 was not observed in any of 
      the lymphomas analyzed. We conclude that the translocations t(11;18)(q21;q21) and 
      t(14;18)(q21;q32) represent the main structural aberrations involving MLT/MALT1 
      in MALT lymphomas, whereas true amplifications of MLT/MALT1 occur rarely in 
      MZBCL.
FAU - Murga Penas, E M
AU  - Murga Penas EM
AD  - Department of Medicine, Hamburg, Germany.
FAU - Hinz, K
AU  - Hinz K
FAU - Roser, K
AU  - Roser K
FAU - Copie-Bergman, C
AU  - Copie-Bergman C
FAU - Wlodarska, I
AU  - Wlodarska I
FAU - Marynen, P
AU  - Marynen P
FAU - Hagemeijer, A
AU  - Hagemeijer A
FAU - Gaulard, P
AU  - Gaulard P
FAU - Loning, T
AU  - Loning T
FAU - Hossfeld, D K
AU  - Hossfeld DK
FAU - Dierlamm, J
AU  - Dierlamm J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proteins)
RN  - EC 3.4.22.- (Caspases)
RN  - EC 3.4.22.- (MALT1 protein, human)
RN  - EC 3.4.22.- (Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein)
SB  - IM
MH  - Breast Neoplasms/pathology
MH  - Caspases
MH  - *Chromosome Aberrations
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 14
MH  - *Chromosomes, Human, Pair 18
MH  - Gastrointestinal Neoplasms/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell, Marginal Zone/*genetics
MH  - Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
MH  - Neoplasm Proteins/*genetics
MH  - Parotid Neoplasms/genetics
MH  - Proteins/*genetics
MH  - Retrospective Studies
MH  - Stomach Neoplasms/genetics
MH  - *Translocation, Genetic
EDAT- 2003/08/22 05:00
MHDA- 2004/02/06 05:00
CRDT- 2003/08/22 05:00
PHST- 2003/08/22 05:00 [pubmed]
PHST- 2004/02/06 05:00 [medline]
PHST- 2003/08/22 05:00 [entrez]
AID - 2403122 [pii]
AID - 10.1038/sj.leu.2403122 [doi]
PST - ppublish
SO  - Leukemia. 2003 Nov;17(11):2225-9. doi: 10.1038/sj.leu.2403122.