PMID- 12931244
OWN - NLM
STAT- MEDLINE
DCOM- 20040505
LR  - 20220227
IS  - 0268-3369 (Print)
IS  - 0268-3369 (Linking)
VI  - 32 Suppl 1
DP  - 2003 Aug
TI  - Hematopoietic stem cell transplantation for severe Crohn's disease.
PG  - S57-9
AB  - It is clear that some patients with severe Crohn's disease (CD) fail to respond 
      favorably to the standard treatment, including antibody to Tumor Necrosis Factor 
      alpha (TNFalpha), We have embarked on a unique therapy for this group of 
      patients, intense immune suppression followed by autologous hematopoietic stem 
      cell transplantation (HSCT). The response to this approach in our first four 
      patients has been excellent, with there being no significant untoward event from 
      the transplantation and with each patient entering clinical remission in terms of 
      the Crohn's Disease Activity Index off all therapy for CD and no diarrhea or 
      abdominal pain. However, some evidence of minor laboratory abnormalities and 
      slight inflammation of the colon on colonoscopic evaluation persist up to 1 year 
      post-transplant. It is suggested that HSCT should be considered a reasonable 
      option for patients who have failed standard CD therapy, although long-term 
      follow-up will be necessary to confirm the duration of the induced clinical 
      remission.
FAU - Craig, R M
AU  - Craig RM
AD  - Division of Immunotherapy, Northwestern University Medical Center, Chicago, IL 
      60611, USA.
FAU - Traynor, A
AU  - Traynor A
FAU - Oyama, Y
AU  - Oyama Y
FAU - Burt, R K
AU  - Burt RK
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
SB  - IM
MH  - Abdominal Pain/etiology
MH  - Adult
MH  - Crohn Disease/complications/*therapy
MH  - Diarrhea/etiology
MH  - Female
MH  - Fever/etiology
MH  - Hematopoietic Stem Cell Transplantation/adverse effects/*methods
MH  - Humans
MH  - Remission Induction
MH  - Salvage Therapy
MH  - Severity of Illness Index
EDAT- 2003/08/22 05:00
MHDA- 2004/05/07 05:00
CRDT- 2003/08/22 05:00
PHST- 2003/08/22 05:00 [pubmed]
PHST- 2004/05/07 05:00 [medline]
PHST- 2003/08/22 05:00 [entrez]
AID - 1703945 [pii]
AID - 10.1038/sj.bmt.1703945 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2003 Aug;32 Suppl 1:S57-9. doi: 10.1038/sj.bmt.1703945.