PMID- 12932356
OWN - NLM
STAT- MEDLINE
DCOM- 20030929
LR  - 20240109
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 19
IP  - 2
DP  - 2003 Aug
TI  - Plasmacytoid dendritic cells induce plasma cell differentiation through type I 
      interferon and interleukin 6.
PG  - 225-34
AB  - Dendritic cells (DCs) initiate and control immune responses. Plasmacytoid DCs 
      (pDCs) represent a unique DC subset able to promptly release large amounts of 
      type I interferon (IFN-alphabeta) upon viral encounter. Here we report that 
      depletion of pDCs from human blood mononuclear cells abrogates the secretion of 
      specific and polyclonal IgGs in response to influenza virus. Furthermore, 
      purified pDCs triggered with virus induce CD40-activated B cells to differentiate 
      into plasma cells. Two pDC cytokines act sequentially, with IFN-alphabeta 
      generating non-Ig-secreting plasma blasts and IL-6 inducing their differentiation 
      into Ig-secreting plasma cells. These plasma cells display the high levels of 
      CD38 found on tissue plasma cells. Thus, pDCs are critical for the generation of 
      plasma cells and antibody responses.
FAU - Jego, Gaetan
AU  - Jego G
AD  - Baylor Institute for Immunology Research, 3434 Live Oak Street, Dallas, Texas 
      75204, USA.
FAU - Palucka, A Karolina
AU  - Palucka AK
FAU - Blanck, Jean-Philippe
AU  - Blanck JP
FAU - Chalouni, Cecile
AU  - Chalouni C
FAU - Pascual, Virginia
AU  - Pascual V
FAU - Banchereau, Jacques
AU  - Banchereau J
LA  - eng
GR  - R01 AR46589/AR/NIAMS NIH HHS/United States
GR  - R01 CA78846/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (CD40 Antigens)
RN  - 0 (Immunoglobulins)
RN  - 0 (Interferon Type I)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Adult
MH  - B-Lymphocytes/immunology
MH  - CD40 Antigens/metabolism
MH  - Cell Communication
MH  - Cell Differentiation
MH  - Dendritic Cells/*cytology/*immunology
MH  - Humans
MH  - Immunoglobulins/biosynthesis
MH  - In Vitro Techniques
MH  - Interferon Type I/*metabolism
MH  - Interleukin-6/*metabolism
MH  - Lymphocyte Activation
MH  - Plasma Cells/*cytology/*immunology
EDAT- 2003/08/23 05:00
MHDA- 2003/09/30 05:00
CRDT- 2003/08/23 05:00
PHST- 2003/08/23 05:00 [pubmed]
PHST- 2003/09/30 05:00 [medline]
PHST- 2003/08/23 05:00 [entrez]
AID - S1074-7613(03)00208-5 [pii]
AID - 10.1016/s1074-7613(03)00208-5 [doi]
PST - ppublish
SO  - Immunity. 2003 Aug;19(2):225-34. doi: 10.1016/s1074-7613(03)00208-5.