PMID- 12934361
OWN - NLM
STAT- MEDLINE
DCOM- 20040810
LR  - 20061115
IS  - 1000-5625 (Print)
IS  - 1000-5625 (Linking)
VI  - 28
IP  - 2
DP  - 2003 Apr
TI  - [Expression of monocyte chemoattractant protein-1 in aorta of early hypertensive 
      rats].
PG  - 145-8
AB  - OBJECTIVE: To investigate the expression of monocyte chemoattractant 
      protein-1(MCP-1) of aorta wall in acute phase of hypertension in rats with 2 
      kidney and 1 clip(2K1C). METHOD: The MCP-1 mRNA on aorta wall was detected by in 
      situ hybridization and reverse transcription-polymerase chain reaction(RT-PCR). 
      RESULTS: No MCP-1 was expressed in normal rat, but it was expressed on the aorta 
      wall of rats in 1 week after 2K1C hypertensive model was formed. The expression 
      of MCP-1 increased with the development of hypertension. CONCLUSION: The 
      expression of MCP-1 on aorta wall of 2K1C hypertensive rats increases in the 
      early stage of hypertension, which may play an important role in accelerating 
      atherosclerosis.
FAU - Xie, Qi-ying
AU  - Xie QY
AD  - Department of Cardiology, Xiangya Hospital, Central South University, Changsha 
      410078, China.
FAU - Sun, Ming
AU  - Sun M
FAU - Yang, Tian-lun
AU  - Yang TL
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Hunan Yi Ke Da Xue Xue Bao
JT  - Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical 
      University
JID - 9424769
RN  - 0 (Chemokine CCL2)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Aorta/*metabolism
MH  - Arteriosclerosis/etiology
MH  - Chemokine CCL2/*biosynthesis/genetics
MH  - Hypertension/complications/*metabolism
MH  - Male
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Rats
MH  - Rats, Wistar
EDAT- 2003/08/26 05:00
MHDA- 2004/08/11 05:00
CRDT- 2003/08/26 05:00
PHST- 2003/08/26 05:00 [pubmed]
PHST- 2004/08/11 05:00 [medline]
PHST- 2003/08/26 05:00 [entrez]
PST - ppublish
SO  - Hunan Yi Ke Da Xue Xue Bao. 2003 Apr;28(2):145-8.