PMID- 12935755
OWN - NLM
STAT- MEDLINE
DCOM- 20031119
LR  - 20190901
IS  - 0378-1135 (Print)
IS  - 0378-1135 (Linking)
VI  - 95
IP  - 4
DP  - 2003 Sep 24
TI  - Infection of porcine reproductive and respiratory syndrome virus suppresses the 
      antibody response to classical swine fever virus vaccination.
PG  - 295-301
AB  - The effects of porcine reproductive and respiratory syndrome virus (PRRSV) 
      infection on the antibody response to vaccination with classical swine fever 
      (CSF) vaccine in piglets were investigated. Piglets were inoculated intranasally 
      with the PRRSV BJ-4 strain, and then vaccinated intramuscularly with CSF vaccine 
      2 days later. Control animals were either vaccinated with CSF vaccine or infected 
      with PRRSV alone. Time course of the antibody response against either PRRSV or 
      CSF vaccine was measured. In animals infected with PRRSV prior to CSF 
      vaccination, the antibody response to CSF vaccine was significantly lower than 
      that observed in animals treated with CSF vaccination alone, especially during 
      3-5 weeks after vaccination. At the same time, no significant difference in serum 
      PRRSV antibody level was observed between the animals treated with both PRRSV and 
      CSF vaccine and the animals treated with PRRSV alone. These results suggested 
      that the reduced antibody response against CSF vaccine observed in PRRSV-infected 
      animals might be related to the higher prevalence of CSF in PRRSV prevalent farms 
      in China.
FAU - Li, Hua
AU  - Li H
AD  - Key Laboratory of Preventive Veterinary Medicine, College of Veterinary Medicine, 
      China Agricultural University, Ministry of Agriculture, Beijing 100094, PR China.
FAU - Yang, Hanchun
AU  - Yang H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (Antibodies, Viral)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Classical Swine Fever/complications/*immunology/prevention & control
MH  - Classical Swine Fever Virus/*immunology
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - Random Allocation
MH  - Specific Pathogen-Free Organisms
MH  - Swine
MH  - Vaccination/veterinary
MH  - Viral Vaccines/*immunology/standards
EDAT- 2003/08/26 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/08/26 05:00
PHST- 2003/08/26 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/08/26 05:00 [entrez]
AID - S0378113503001585 [pii]
AID - 10.1016/s0378-1135(03)00158-5 [doi]
PST - ppublish
SO  - Vet Microbiol. 2003 Sep 24;95(4):295-301. doi: 10.1016/s0378-1135(03)00158-5.