PMID- 12938525
OWN - NLM
STAT- MEDLINE
DCOM- 20151123
LR  - 20240202
IS  - 0257-716X (Print)
IS  - 0257-716X (Linking)
VI  - 19
IP  - 4
DP  - 1999
TI  - Experimental study on detached renal tubular epithelial cells in urine of 
      nephropathia epidemic patients.
PG  - 307-9
AB  - To elucidate the pathogenesis of acute renal failure (ARF) with nephropathia 
      epidemic (NE), provide experimental evidence for the new therapy to NE and 
      observe the effects of Arg-Gly-Asp (RGD) peptides on adhesion of renal tubular 
      epithelial cell (RTEC), urine specimens of patients were collected under sterile 
      conditions. Detached RTECs were separated, cultured and identified. Hantan Virus 
      antigen was determined by using indirect immunofluorescence method and effects of 
      RGD on adhesion of RTECs was observed by subgroup counting as well as by flow 
      cytometry. This study showed that: (1) sublethal RTECs existed in the urine of 
      NE-ARF patients, which could be cultured in monolayer form; (2) there was NE 
      antigen in RTECs; and (3) adhesion of RTECs could be inhibited by RGD.
FAU - Deng, A
AU  - Deng A
AD  - Department of Nephrology, Xiehe Hospital, Tongji Medical University, Wuhan 
      430022.
FAU - Yang, X
AU  - Yang X
FAU - Wu, C
AU  - Wu C
FAU - Yao, L
AU  - Yao L
FAU - Li, Y
AU  - Li Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - J Tongji Med Univ
JT  - Journal of Tongji Medical University = Tong ji yi ke da xue xue bao
JID - 8605495
RN  - 0 (Antigens)
RN  - 0 (Oligopeptides)
RN  - 78VO7F77PN (arginyl-glycyl-aspartic acid)
SB  - IM
MH  - Acute Kidney Injury/*urine
MH  - Antigens
MH  - Cell Adhesion
MH  - Epithelial Cells
MH  - Humans
MH  - Kidney Tubules/cytology
MH  - Oligopeptides/*pharmacology
EDAT- 2003/08/27 05:00
MHDA- 2015/12/15 06:00
CRDT- 2003/08/27 05:00
PHST- 2003/08/27 05:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2003/08/27 05:00 [entrez]
AID - 10.1007/BF02886970 [doi]
PST - ppublish
SO  - J Tongji Med Univ. 1999;19(4):307-9. doi: 10.1007/BF02886970.