PMID- 12939427
OWN - NLM
STAT- MEDLINE
DCOM- 20040129
LR  - 20190514
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 61
IP  - 4
DP  - 2003 Aug 26
TI  - Myelin basic protein gene is associated with MS in DR4- and DR5-positive Italians 
      and Russians.
PG  - 520-6
AB  - BACKGROUND: The myelin basic protein (MBP) gene may confer genetic susceptibility 
      to multiple sclerosis (MS). The association of MS with alleles of the (TGGA)n 
      variable number tandem repeat (VNTR) 5' to the MBP gene is the subject of 
      conflicting reports. OBJECTIVE: To study possible MS association with VNTR 
      alleles of MBP gene in ethnic Italians and ethnic Russians. METHODS: Two hundred 
      sixty-nine unrelated patients with definite MS and 385 unrelated healthy control 
      subjects from Italy and Russia were genotyped for the MBP VNTR region and for the 
      human leukocyte antigen (HLA) class II DRB1 gene. The phenotype, allele, and 
      genotype frequencies for two groups of MBP alleles were determined. Patients and 
      control subjects were stratified according to HLA-DRB1 phenotypes. RESULTS: The 
      distribution of MBP alleles and genotypes in the two ethnic groups, including 
      both MS patients and control subjects, was very similar. When MS patients and 
      healthy control subjects were stratified according to HLA-DRB1 phenotypes, a 
      significant association of MS with MBP alleles was found only in the DR4- and 
      DR5-positive subgroups. A significant association with MBP alleles was also 
      observed in the nonstratified groups, owing mainly to the contribution of the 
      DR4- and DR5-positive individuals. CONCLUSION: Polymorphism of the MBP or another 
      gene in its vicinity appears to contribute to the etiology of MS for the 
      subgroups of DR4- and DR5-positive Italians and Russians.
FAU - Guerini, F R
AU  - Guerini FR
AD  - Laboratory of Biology, Don C. Gnocchi Foundation, ONLUS, IRCCS, Italy.
FAU - Ferrante, P
AU  - Ferrante P
FAU - Losciale, L
AU  - Losciale L
FAU - Caputo, D
AU  - Caputo D
FAU - Lombardi, M L
AU  - Lombardi ML
FAU - Pirozzi, G
AU  - Pirozzi G
FAU - Luongo, V
AU  - Luongo V
FAU - Sudomoina, M A
AU  - Sudomoina MA
FAU - Andreewski, T V
AU  - Andreewski TV
FAU - Alekseenkov, A D
AU  - Alekseenkov AD
FAU - Boiko, A N
AU  - Boiko AN
FAU - Gusev, E I
AU  - Gusev EI
FAU - Favorova, O O
AU  - Favorova OO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (HLA-DR4 Antigen)
RN  - 0 (HLA-DR5 Antigen)
RN  - 0 (Myelin Basic Protein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DR4 Antigen/*genetics
MH  - HLA-DR5 Antigen/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Italy
MH  - Male
MH  - Middle Aged
MH  - *Minisatellite Repeats
MH  - Multiple Sclerosis/ethnology/*genetics
MH  - Myelin Basic Protein/*genetics
MH  - Russia
EDAT- 2003/08/27 05:00
MHDA- 2004/01/30 05:00
CRDT- 2003/08/27 05:00
PHST- 2003/08/27 05:00 [pubmed]
PHST- 2004/01/30 05:00 [medline]
PHST- 2003/08/27 05:00 [entrez]
AID - 10.1212/01.wnl.0000079372.54703.a8 [doi]
PST - ppublish
SO  - Neurology. 2003 Aug 26;61(4):520-6. doi: 10.1212/01.wnl.0000079372.54703.a8.