PMID- 12939594
OWN - NLM
STAT- MEDLINE
DCOM- 20031007
LR  - 20061115
IS  - 0270-9139 (Print)
IS  - 0270-9139 (Linking)
VI  - 38
IP  - 3
DP  - 2003 Sep
TI  - Interleukin 6 is important for survival after partial hepatectomy in mice.
PG  - 674-82
AB  - The response to partial hepatectomy (PH) is impaired in interleukin 6 
      (IL-6)-deficient mice. IL-6 is well known for its role in the induction of the 
      acute phase (AP) response, and the impairment of this response after surgery and 
      hepatectomy could explain the defective hepatocyte regeneration. In addition, it 
      was proposed that IL-6 has an important role in stimulating the reentry of 
      quiescent cells into the cell cycle within the first 2 to 4 hours after PH. To 
      further analyze the role for IL-6, we performed two third hepatectomies in 
      wild-type mice, in IL-6 knockout (KO) mice, and in IL-6 KO mice that were treated 
      30 minutes before surgery with intravenous (IV) (short acting) or subcutaneous 
      (SC) (long acting) injections of recombinant IL-6. The high postoperative 
      mortality of IL-6-deficient mice could be completely prevented by SC, but not by 
      IV IL-6 treatment, showing the requirement of a sustained action of IL-6. 
      However, there is a subset of IL-6 KO mice that survives a PH in good health even 
      without IL-6 treatment. When we analyzed these mice, we found an intact liver 
      regeneration and no indication of a block in cell cycle reentry. We conclude that 
      the major role of IL-6 is the induction of an adaptive response to PH that 
      ensures body homeostasis and survival.
FAU - Blindenbacher, Alex
AU  - Blindenbacher A
AD  - Department of Research, University Hospital Basel, Basel, Switzerland.
FAU - Wang, Xueya
AU  - Wang X
FAU - Langer, Igor
AU  - Langer I
FAU - Savino, Rocco
AU  - Savino R
FAU - Terracciano, Luigi
AU  - Terracciano L
FAU - Heim, Markus H
AU  - Heim MH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hepatology
JT  - Hepatology (Baltimore, Md.)
JID - 8302946
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Interleukin-6)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (Stat3 protein, mouse)
RN  - 0 (Trans-Activators)
SB  - IM
CIN - Hepatology. 2003 Dec;38(6):1590-1; author reply 1591. PMID: 14647070
MH  - Acute-Phase Proteins/metabolism
MH  - Animals
MH  - Cell Cycle
MH  - DNA-Binding Proteins/metabolism
MH  - *Hepatectomy/methods/mortality
MH  - Injections, Subcutaneous
MH  - Interleukin-6/administration & dosage/*metabolism
MH  - Liver/pathology
MH  - Liver Regeneration
MH  - Mice
MH  - Mice, Knockout
MH  - STAT3 Transcription Factor
MH  - Survival Rate
MH  - Time Factors
MH  - Trans-Activators/metabolism
EDAT- 2003/08/27 05:00
MHDA- 2003/10/08 05:00
CRDT- 2003/08/27 05:00
PHST- 2003/08/27 05:00 [pubmed]
PHST- 2003/10/08 05:00 [medline]
PHST- 2003/08/27 05:00 [entrez]
AID - S0270913903006694 [pii]
AID - 10.1053/jhep.2003.50378 [doi]
PST - ppublish
SO  - Hepatology. 2003 Sep;38(3):674-82. doi: 10.1053/jhep.2003.50378.