PMID- 12940513
OWN - NLM
STAT- MEDLINE
DCOM- 20040210
LR  - 20161018
IS  - 1434-6621 (Print)
IS  - 1434-6621 (Linking)
VI  - 41
IP  - 7
DP  - 2003 Jul
TI  - Polymorphisms in the IL-4 and IL-4R [alpha] genes and allergic asthma.
PG  - 888-92
AB  - Allergic asthma is caused by genetic and environmental factors that interact to 
      determine disease susceptibility and severity. Several lines of evidence suggest 
      that the interleukin (IL-4 gene and the IL-4-receptor alpha (IL-4Ralpha) gene are 
      involved in the development of atopic diseases. We sought to determine whether 
      two polymorphism sites in IL-4 and IL-4Ralpha chain were associated with allergic 
      asthma in a Chinese population. We obtained DNA and clinical data from allergic 
      asthma patients, which were compared with those of a group of healthy control 
      subjects. The subjects were genotyped for the IL-4 C-590T promoter polymorphism 
      and the IL-4R alpha chain Q576R by polymerase chain reaction-restriction fragment 
      length polymorphism. The results showed that the IL-4 C-590T was not associated 
      with allergic asthma in a Chinese population. However, the IL-4R alpha chain 
      576R/R was significantly increased in allergic asthma patients compared with 
      control subjects (chi2 = 21.16; p < 0.01), and also total plasma immunoglobulin E 
      (IgE) level was increased in allergic asthma patients. These data suggest that 
      the IL-4R alpha chain 576R/R genotypes confer genetic susceptibility to allergic 
      asthma in Chinese.
FAU - Cui, Tianpen
AU  - Cui T
AD  - Immunology Laboratory, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, P.R. of China. 
      Tianpencui@hotmail.com
FAU - Wu, Jianmin
AU  - Wu J
FAU - Pan, Shixiu
AU  - Pan S
FAU - Xie, Jungang
AU  - Xie J
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 0 (Receptors, Interleukin-4)
RN  - 207137-56-2 (Interleukin-4)
SB  - IM
MH  - Asthma/diagnosis/*genetics/*immunology
MH  - China
MH  - Europe
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Interleukin-4/*genetics
MH  - *Polymorphism, Genetic
MH  - Receptors, Interleukin-4/*genetics
MH  - Reference Values
MH  - Respiratory Function Tests
MH  - United States
EDAT- 2003/08/28 05:00
MHDA- 2004/02/11 05:00
CRDT- 2003/08/28 05:00
PHST- 2003/08/28 05:00 [pubmed]
PHST- 2004/02/11 05:00 [medline]
PHST- 2003/08/28 05:00 [entrez]
AID - 10.1515/CCLM.2003.134 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2003 Jul;41(7):888-92. doi: 10.1515/CCLM.2003.134.