PMID- 12940539
OWN - NLM
STAT- MEDLINE
DCOM- 20031224
LR  - 20220408
IS  - 0301-0430 (Print)
IS  - 0301-0430 (Linking)
VI  - 60 Suppl 1
DP  - 2003 Jul
TI  - The cardio renal anemia syndrome: correcting anemia in patients with resistant 
      congestive heart failure can improve both cardiac and renal function and reduce 
      hospitalizations.
PG  - S93-102
AB  - Anemia (Hemoglobin of < 12 to 13 g/dl) is frequently encountered in patients with 
      congestive heart failure (CHF). This anemia may be partly due to hemodilution, 
      partly to the associated reduction in renal function, and partly to the use of 
      ACE inhibitors and aspirin. However, there is evidence that CHF alone--through 
      excessive cytokine production may also reduce the bone marrow and cause anemia. 
      In several recent studies anemia has been found to be associated with a more 
      severe degree of CHF, a higher rate of death, renal failure, hospitalization and 
      evidence of malnutrition. In both uncontrolled and controlled studies correction 
      of anemia with erythropoietin with or without the addition of i.v. iron has been 
      attempted. The correction of anemia has been associated with a marked improvement 
      in New York Heart Association (NYHA) functional cardiac class and Left 
      Ventricular Ejection Fraction, a marked reduction in the need for hospitalization 
      and high dose oral and i.v. diuretics, and an improvement in exercise capacity, 
      peak exercise oxygen utilization and quality of life. The serum creatinine, which 
      had been increasing steadily before treatment, stabilized with the correction of 
      anemia. All this suggests that control of anemia in CHF could become a valuable 
      addition to the therapeutic armamentarium of CHF and might also play a major role 
      in the prevention of progressive renal failure.
FAU - Silverberg, D S
AU  - Silverberg DS
AD  - Department of Nephrology and Cardiology, Tel Aviv Sourasky Medical Center, Tel 
      Aviv, Israel. donald@netvision.net.il
FAU - Wexler, D
AU  - Wexler D
FAU - Blum, M
AU  - Blum M
FAU - Iaina, A
AU  - Iaina A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Clin Nephrol
JT  - Clinical nephrology
JID - 0364441
SB  - IM
MH  - Anemia/*complications/physiopathology/*therapy
MH  - Heart Failure/*complications/physiopathology/therapy
MH  - *Hospitalization
MH  - Humans
MH  - Kidney Diseases/*complications/physiopathology/therapy
MH  - Kidney Failure, Chronic/physiopathology/*prevention & control
MH  - Syndrome
RF  - 60
EDAT- 2003/08/28 05:00
MHDA- 2003/12/25 05:00
CRDT- 2003/08/28 05:00
PHST- 2003/08/28 05:00 [pubmed]
PHST- 2003/12/25 05:00 [medline]
PHST- 2003/08/28 05:00 [entrez]
PST - ppublish
SO  - Clin Nephrol. 2003 Jul;60 Suppl 1:S93-102.