PMID- 12941447
OWN - NLM
STAT- MEDLINE
DCOM- 20031015
LR  - 20190916
IS  - 0168-0102 (Print)
IS  - 0168-0102 (Linking)
VI  - 47
IP  - 1
DP  - 2003 Sep
TI  - Enhancement of neurogenesis by running wheel exercises is suppressed in mice 
      lacking NMDA receptor epsilon 1 subunit.
PG  - 55-63
AB  - Neurogenesis continues throughout adulthood in the dentate gyrus in mice, and is 
      regulated by environmental, endocrine, and pharmacological stimuli. Although 
      running wheel exercises have been reported to enhance neurogenesis, details of 
      molecule mechanisms of the enhancement are not well understood. We report here 
      that the hippocampal neurogenesis is enhanced when wild-type mice are raised in 
      cages with running wheels for 3 weeks, but the wheel exercise does not enhance 
      the neurogenesis in mice lacking the NMDA receptor epsilon1 subunit. 
      Brain-derived neurotrophic factor (BDNF) has been reported to affect neuronal 
      cell proliferation and survival. We examined the BDNF levels in the hippocampi of 
      wild-type and epsilon1 knockout mice, and found that the BDNF level was increased 
      through wheel exercises in the wild-type but not in the knockout mice. The 
      enhancement of neurogenesis by the wheel exercise was also found to be 
      reversible: when the exercise-stimulated wild-type mice were returned to the 
      environment without running wheels for 3 weeks, the neurogenesis was the same as 
      that in the mice which had never experienced the exercise. These results suggest 
      that the wheel exercise may activate NMDA receptors in the hippocampus, which in 
      turn may enhance BDNF production and neurogenesis.
FAU - Kitamura, T
AU  - Kitamura T
AD  - Department of Biology, Graduate School of Science, Kyushu University, 6-10-1 
      Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
FAU - Mishina, M
AU  - Mishina M
FAU - Sugiyama, H
AU  - Sugiyama H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Res
JT  - Neuroscience research
JID - 8500749
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (NR2A NMDA receptor)
RN  - 0 (Protein Subunits)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/biosynthesis
MH  - *Down-Regulation/genetics
MH  - Hippocampus/*growth & development/metabolism/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Motor Activity/genetics/*physiology
MH  - Protein Subunits/*deficiency/genetics/*physiology
MH  - Receptors, N-Methyl-D-Aspartate/*deficiency/genetics/*physiology
EDAT- 2003/08/28 05:00
MHDA- 2003/10/16 05:00
CRDT- 2003/08/28 05:00
PHST- 2003/08/28 05:00 [pubmed]
PHST- 2003/10/16 05:00 [medline]
PHST- 2003/08/28 05:00 [entrez]
AID - S0168010203001718 [pii]
AID - 10.1016/s0168-0102(03)00171-8 [doi]
PST - ppublish
SO  - Neurosci Res. 2003 Sep;47(1):55-63. doi: 10.1016/s0168-0102(03)00171-8.