PMID- 12941542
OWN - NLM
STAT- MEDLINE
DCOM- 20040416
LR  - 20190906
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 64
IP  - 9
DP  - 2003 Sep
TI  - Coxsackie virus B antibodies are increased in HLA DR3-MICA5.1 positive type 1 
      diabetes patients in the Linkoping region of Sweden.
PG  - 874-9
AB  - Type 1 diabetes mellitus (T1DM) is an autoimmune disorder in which genetics and 
      environmental factors play a role. Among the environmental factors, viruses 
      (especially Coxsackie virus B [CBV]), and among genetic markers, human leukocyte 
      antigen (HLA) DRB1*04-DQA1*0301-DQB1*0302 (DR4-DQ8) and 
      DRB1*03-DQA1*0501-DQB1*0201 (DR3-DQ2), and major histocompatibility complex class 
      I chain-related gene-A (MICA) alleles 5 and 5.1 have been reported to be 
      associated with T1DM in Caucasians. Sweden ranks third in the world for T1DM 
      incidence. In Sweden, the Linkoping region indicates the highest incidence for 
      T1DM. In this study, we analyzed whether antibodies against CBV are increased in 
      DR3, DR4, MICA5, or MICA5.1 positive patients from Linkoping (n = 46) and from 
      Swedish population as a whole (n = 298) between the age of 0 and 15 years old. 
      There was no difference in the frequency of antibodies to CBV in patients 
      compared with controls in Linkoping (26% vs 23%) or in all of Sweden (26% vs 
      21%). However, CBV antibodies were increased in DR3, DR3-DR4 (heterozygous), 
      DR3-MICA5.1, and DR3-DR4-MICA5.1 positive compared with DR3, DR3-DR4, 
      DR3-MICA5.1, and DR3-DR4-MICA5.1 negative patients in Linkoping (p < 0.05 for 
      all), but not in Swedish population as a whole. Thus, our study suggests that in 
      addition to DR3, MICA5.1 has an influence on the immune response to CBV infection 
      in patients from Linkoping.
FAU - Gupta, Manu
AU  - Gupta M
AD  - Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
FAU - Nikitina-Zake, Liene
AU  - Nikitina-Zake L
FAU - Landin-Olsson, Mona
AU  - Landin-Olsson M
FAU - Kockum, Ingrid
AU  - Kockum I
FAU - Sanjeevi, Carani B
AU  - Sanjeevi CB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Antibodies, Viral)
RN  - 0 (HLA-DR3 Antigen)
RN  - 0 (HLA-DR4 Antigen)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
SB  - IM
MH  - Adolescent
MH  - Antibodies, Viral/*biosynthesis
MH  - Diabetes Mellitus, Type 1/genetics/*immunology/*virology
MH  - Enterovirus B, Human/*immunology
MH  - Enterovirus Infections/immunology
MH  - HLA-DR3 Antigen/*analysis
MH  - HLA-DR4 Antigen/analysis
MH  - Histocompatibility Antigens Class I/*analysis/genetics
MH  - Humans
MH  - Retrospective Studies
MH  - Sweden
EDAT- 2003/08/28 05:00
MHDA- 2004/04/17 05:00
CRDT- 2003/08/28 05:00
PHST- 2003/08/28 05:00 [pubmed]
PHST- 2004/04/17 05:00 [medline]
PHST- 2003/08/28 05:00 [entrez]
AID - S0198885903001496 [pii]
AID - 10.1016/s0198-8859(03)00149-6 [doi]
PST - ppublish
SO  - Hum Immunol. 2003 Sep;64(9):874-9. doi: 10.1016/s0198-8859(03)00149-6.