PMID- 12941548
OWN - NLM
STAT- MEDLINE
DCOM- 20040416
LR  - 20190906
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 64
IP  - 9
DP  - 2003 Sep
TI  - HLA haplotype is associated with diabetes among atomic bomb survivors.
PG  - 910-6
AB  - We examined radiation effects on the relationship between diabetes development 
      and genetic background in atomic-bomb (A-bomb) survivors. Our main aim in this 
      study was to shed light on the role of genetic background in diabetes onset among 
      A-bomb survivors by studying possible relationships between human leukocyte 
      antigen (HLA) genotypes and the diabetes in patients and controls. We examined 
      the effects of different HLA haplotypes on type 2 diabetes development by 
      determining the DQA1 and DRB1 alleles of Hiroshima A-bomb survivors (111 diabetic 
      patients and 774 controls) using the polymerase chain reaction-sequence specific 
      oligonucleotide probes (PCR-SSOP) method. We noted an increased risk of diabetes 
      in the higher dose group among these patients (trend p = 0.001). The risk of the 
      most heavily exposed group was significantly higher than that of the unexposed 
      group or the low-dose group especially in survivors with the DQA1*03-DRB1*09 or 
      DQA1*0401-DRB1*08 haplotypes (trend p = 0.002 or p = 0.05, respectively). By 
      contrast, in people with other haplotypes, the risk did not increase 
      significantly with increasing dose. These results suggest that individuals with 
      specific HLA haplotypes may have an increased risk of diabetes with 
      increased-dose categories.
FAU - Hayashi, Tomonori
AU  - Hayashi T
AD  - Department of Radiobiology/Molecular Epidemiology, Radiation Effects Research 
      Foundation, Hiroshima, Japan. tomo@rerf.or.jp
FAU - Fujiwara, Saeko
AU  - Fujiwara S
FAU - Morishita, Yukari
AU  - Morishita Y
FAU - Kusunoki, Yoichiro
AU  - Kusunoki Y
FAU - Nakashima, Eiji
AU  - Nakashima E
FAU - Nakanishi, Shuhei
AU  - Nakanishi S
FAU - Suzuki, Gen
AU  - Suzuki G
FAU - Nakachi, Kei
AU  - Nakachi K
FAU - Kyoizumi, Seishi
AU  - Kyoizumi S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Aged
MH  - Diabetes Mellitus, Type 2/diagnosis/*genetics/immunology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics/immunology/radiation effects
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Nuclear Warfare
MH  - *Survivors
EDAT- 2003/08/28 05:00
MHDA- 2004/04/17 05:00
CRDT- 2003/08/28 05:00
PHST- 2003/08/28 05:00 [pubmed]
PHST- 2004/04/17 05:00 [medline]
PHST- 2003/08/28 05:00 [entrez]
AID - S0198885903001575 [pii]
AID - 10.1016/s0198-8859(03)00157-5 [doi]
PST - ppublish
SO  - Hum Immunol. 2003 Sep;64(9):910-6. doi: 10.1016/s0198-8859(03)00157-5.