PMID- 12942394
OWN - NLM
STAT- MEDLINE
DCOM- 20031006
LR  - 20131121
IS  - 1537-6591 (Electronic)
IS  - 1058-4838 (Linking)
VI  - 37
IP  - 5
DP  - 2003 Sep 1
TI  - Epidemiological comparison of true methicillin-resistant and 
      methicillin-susceptible coagulase-negative staphylococcal bacteremia at hospital 
      admission.
PG  - 644-9
AB  - We performed 2 case-control studies among 108 patients with true 
      coagulase-negative staphylococcal (CoNS) bacteremia diagnosed within 48 h of 
      hospital admission. Seventy-nine patients (73%) with methicillin-resistant (MR) 
      CoNS bacteremia and 29 patients (27%) with methicillin-susceptible (MS) CoNS 
      bacteremia were compared with 79 randomly selected control patients without CoNS 
      bacteremia. The presence of a central venous catheter was an independent risk 
      factor for both MR- and MS-CoNS bacteremia (P<.001). Patients with MR-CoNS 
      bacteremia were more frequently admitted from health care facilities (P=.02), 
      more likely to have had previous MR Staphylococcus aureus infection or 
      colonization (P=.02), and more likely to have received antibiotics in the 
      previous 30 days (P=.02). The probability that bacteremia was caused by an MR 
      strain, rather than an MS strain, was 62% among patients admitted from the 
      community and 84% among patients admitted from health care facilities. This study 
      identified epidemiological characteristics that can be used to distinguish 
      between MR- and MS-CoNS bacteremia and found high rates of methicillin resistance 
      among CoNS isolates recovered from patients admitted from the community, as well 
      as from health care facilities.
FAU - Tacconelli, Evelina
AU  - Tacconelli E
AD  - Beth Israel Deaconess Medical Center and Division of Infectious Diseases, Harvard 
      Medical School, Boston, Massachusetts 02215, USA. etaccone@bidmc.harvard.edu
FAU - D'Agata, Erika M C
AU  - D'Agata EM
FAU - Karchmer, Adolf W
AU  - Karchmer AW
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20030815
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases 
      Society of America
JID - 9203213
RN  - 0 (Coagulase)
RN  - Q91FH1328A (Methicillin)
SB  - IM
MH  - Bacteremia/drug therapy/*epidemiology
MH  - Case-Control Studies
MH  - *Coagulase
MH  - Diagnostic Tests, Routine
MH  - Drug Resistance, Microbial
MH  - Enterobacter/drug effects/isolation & purification
MH  - Enterobacteriaceae Infections/diagnosis/drug therapy/epidemiology/metabolism
MH  - Escherichia coli/drug effects/isolation & purification
MH  - Escherichia coli Infections/diagnosis/drug therapy/epidemiology/metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Methicillin/metabolism/*therapeutic use
MH  - Methicillin Resistance/*physiology
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Pseudomonas Infections/diagnosis/drug therapy/epidemiology/metabolism
MH  - Pseudomonas aeruginosa/drug effects/isolation & purification
MH  - Staphylococcal Infections/diagnosis/drug therapy/*epidemiology/metabolism
MH  - Staphylococcus aureus/*drug effects/enzymology/isolation & purification
EDAT- 2003/08/28 05:00
MHDA- 2003/10/08 05:00
CRDT- 2003/08/28 05:00
PHST- 2003/02/20 00:00 [received]
PHST- 2003/04/14 00:00 [accepted]
PHST- 2003/08/28 05:00 [pubmed]
PHST- 2003/10/08 05:00 [medline]
PHST- 2003/08/28 05:00 [entrez]
AID - CID30994 [pii]
AID - 10.1086/377207 [doi]
PST - ppublish
SO  - Clin Infect Dis. 2003 Sep 1;37(5):644-9. doi: 10.1086/377207. Epub 2003 Aug 15.